Bax and Bcl-2 protein expression in gastric precancerous lesions: immunohistochemical study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Anagnostopoulos, G. K.
Stefanou, D.
Arkoumani, E.
Sakorafas, G.
Pavlakis, G.
Arvanitidis, D.
Tsianos, E.
Agnantis, N. J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Gastroenterol Hepatol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND AND AIMS: Bcl-2 protein prolongs cell survival in the face of classical apoptotic stimuli, and is considered to be a suppressor of apoptosis. Bax plays a key role in apoptosis by accelerating cell death after an apoptotic stimulus. The aim of our study was to determine the roles of the Bax proapoptotic gene and the Bcl-2 antiapoptotic gene in the carcinogenesis of gastric cancer. METHODS: One hundred and forty-five gastric biopsy specimens of chronic gastritis, atrophic gastritis, intestinal metaplasia and gastric dysplasia were studied. Using immunohistochemical methods, Bax and Bcl-2 protein expression was observed. RESULTS: Bax was expressed in epithelial cells in all cases of chronic gastritis. Bax was not detected in 26% of specimens of atrophic gastritis. As intestinal metaplasia develops, Bax is further suppressed. In biopsy samples with dysplasia, Bax expression was demonstrated only in 12% of biopsy samples. Although Bcl-2 protein was not detected in chronic gastritis, aberrant expression was found in gastric epithelial intestinal metaplasia and dysplasia. CONCLUSIONS: The suppression of Bax and overexpression of Bcl-2 protein is an early event in gastric tumorigenesis, before gastric dysplastic changes occur.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Gastritis/metabolism, Gastritis, Atrophic/metabolism, Humans, Immunohistochemistry, Intestines/metabolism/pathology, Male, Metaplasia, Middle Aged, Precancerous Conditions/*metabolism/pathology, Proto-Oncogene Proteins c-bcl-2/*metabolism, Stomach Neoplasms/*metabolism/pathology, bcl-2-Associated X Protein/*metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16246184
http://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2005.04057.x/asset/j.1440-1746.2005.04057.x.pdf?v=1&t=h0f1g1xq&s=3a6752d66ba4cf19686305c48af6e106eb6b44c1
http://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2005.04057.x/asset/j.1440-1746.2005.04057.x.pdf?v=1&t=h0f1g1xq&s=3a6752d66ba4cf19686305c48af6e106eb6b44c1
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής