Bax and Bcl-2 protein expression in gastric precancerous lesions: immunohistochemical study

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dc.contributor.authorAnagnostopoulos, G. K.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorSakorafas, G.en
dc.contributor.authorPavlakis, G.en
dc.contributor.authorArvanitidis, D.en
dc.contributor.authorTsianos, E.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:33:28Z
dc.date.available2015-11-24T19:33:28Z
dc.identifier.issn0815-9319-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23539
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectChronic Diseaseen
dc.subjectFemaleen
dc.subjectGastritis/metabolismen
dc.subjectGastritis, Atrophic/metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIntestines/metabolism/pathologyen
dc.subjectMaleen
dc.subjectMetaplasiaen
dc.subjectMiddle Ageden
dc.subjectPrecancerous Conditions/*metabolism/pathologyen
dc.subjectProto-Oncogene Proteins c-bcl-2/*metabolismen
dc.subjectStomach Neoplasms/*metabolism/pathologyen
dc.subjectbcl-2-Associated X Protein/*metabolismen
dc.titleBax and Bcl-2 protein expression in gastric precancerous lesions: immunohistochemical studyen
heal.abstractBACKGROUND AND AIMS: Bcl-2 protein prolongs cell survival in the face of classical apoptotic stimuli, and is considered to be a suppressor of apoptosis. Bax plays a key role in apoptosis by accelerating cell death after an apoptotic stimulus. The aim of our study was to determine the roles of the Bax proapoptotic gene and the Bcl-2 antiapoptotic gene in the carcinogenesis of gastric cancer. METHODS: One hundred and forty-five gastric biopsy specimens of chronic gastritis, atrophic gastritis, intestinal metaplasia and gastric dysplasia were studied. Using immunohistochemical methods, Bax and Bcl-2 protein expression was observed. RESULTS: Bax was expressed in epithelial cells in all cases of chronic gastritis. Bax was not detected in 26% of specimens of atrophic gastritis. As intestinal metaplasia develops, Bax is further suppressed. In biopsy samples with dysplasia, Bax expression was demonstrated only in 12% of biopsy samples. Although Bcl-2 protein was not detected in chronic gastritis, aberrant expression was found in gastric epithelial intestinal metaplasia and dysplasia. CONCLUSIONS: The suppression of Bax and overexpression of Bcl-2 protein is an early event in gastric tumorigenesis, before gastric dysplastic changes occur.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1440-1746.2005.04057.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16246184-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2005.04057.x/asset/j.1440-1746.2005.04057.x.pdf?v=1&t=h0f1g1xq&s=3a6752d66ba4cf19686305c48af6e106eb6b44c1-
heal.journalNameJ Gastroenterol Hepatolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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