Alterations in electrolyte equilibrium in patients with acute leukemia
Φόρτωση...
Ημερομηνία
Συγγραφείς
Filippatos, T. D.
Milionis, H. J.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Haematol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND AND AIM: A wide array of disturbances in electrolyte equilibrium is commonly seen in patients with acute leukemia (AL). These abnormalities present a potential hazard in these patients, as that of enhancing the cardiotoxic effects of certain chemotherapeutic regimens. The literature dealing with AL-related electrolyte abnormalities and their interactions in leukemic patients was reviewed. DATA SYNTHESIS: Sources included MEDLINE and EMBASE. The search strategy was based on the combination of 'acute leukemia', 'electrolyte abnormalities', 'acid-base disorders', 'potassium', 'sodium', 'magnesium', 'calcium', and 'phosphorus'. References of retrieved articles were also screened. A decrease in serum potassium, mainly owing to lysozyme-induced tubular damage, appears to be one of the most frequent and potentially hazardous abnormalities. Other clinically significant metabolic perturbations include hyponatremia and hypercalcemia. CONCLUSION: A broad spectrum of electrolyte abnormalities is encountered in the clinical setting of AL, which are related to the disease process per se and/or to the therapeutic interventions. Clinicians should be vigilant for early detection and appropriate management of these disorders before the initiation of chemotherapy regimens as well as during treatment.
Περιγραφή
Λέξεις-κλειδιά
*Acid-Base Imbalance/etiology/metabolism, Antineoplastic Agents/adverse effects/metabolism/therapeutic use, Heart Diseases/chemically induced, Humans, *Leukemia/complications/drug therapy/metabolism, Medline, *Water-Electrolyte Imbalance/etiology/metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16313256
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.2005.00547.x/asset/j.1600-0609.2005.00547.x.pdf?v=1&t=h0m64jn6&s=658d21e2a1cd26afc6e4951c0131bf2a0f254d52
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.2005.00547.x/asset/j.1600-0609.2005.00547.x.pdf?v=1&t=h0m64jn6&s=658d21e2a1cd26afc6e4951c0131bf2a0f254d52
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής