Alterations in electrolyte equilibrium in patients with acute leukemia
| dc.contributor.author | Filippatos, T. D. | en |
| dc.contributor.author | Milionis, H. J. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T19:36:57Z | |
| dc.date.available | 2015-11-24T19:36:57Z | |
| dc.identifier.issn | 0902-4441 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23967 | |
| dc.rights | Default Licence | - |
| dc.subject | *Acid-Base Imbalance/etiology/metabolism | en |
| dc.subject | Antineoplastic Agents/adverse effects/metabolism/therapeutic use | en |
| dc.subject | Heart Diseases/chemically induced | en |
| dc.subject | Humans | en |
| dc.subject | *Leukemia/complications/drug therapy/metabolism | en |
| dc.subject | Medline | en |
| dc.subject | *Water-Electrolyte Imbalance/etiology/metabolism | en |
| dc.title | Alterations in electrolyte equilibrium in patients with acute leukemia | en |
| heal.abstract | BACKGROUND AND AIM: A wide array of disturbances in electrolyte equilibrium is commonly seen in patients with acute leukemia (AL). These abnormalities present a potential hazard in these patients, as that of enhancing the cardiotoxic effects of certain chemotherapeutic regimens. The literature dealing with AL-related electrolyte abnormalities and their interactions in leukemic patients was reviewed. DATA SYNTHESIS: Sources included MEDLINE and EMBASE. The search strategy was based on the combination of 'acute leukemia', 'electrolyte abnormalities', 'acid-base disorders', 'potassium', 'sodium', 'magnesium', 'calcium', and 'phosphorus'. References of retrieved articles were also screened. A decrease in serum potassium, mainly owing to lysozyme-induced tubular damage, appears to be one of the most frequent and potentially hazardous abnormalities. Other clinically significant metabolic perturbations include hyponatremia and hypercalcemia. CONCLUSION: A broad spectrum of electrolyte abnormalities is encountered in the clinical setting of AL, which are related to the disease process per se and/or to the therapeutic interventions. Clinicians should be vigilant for early detection and appropriate management of these disorders before the initiation of chemotherapy regimens as well as during treatment. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1111/j.1600-0609.2005.00547.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16313256 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.2005.00547.x/asset/j.1600-0609.2005.00547.x.pdf?v=1&t=h0m64jn6&s=658d21e2a1cd26afc6e4951c0131bf2a0f254d52 | - |
| heal.journalName | Eur J Haematol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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