Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas
Φόρτωση...
Ημερομηνία
Συγγραφείς
Likaki-Karatza, E.
Ravazoula, P.
Androutsopoulos, G. P.
Michail, G.
Batistatou, A.
Tzorakoleftherakis, E.
Kalofonos, H.
Kourounis, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Gynaecol Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The aim of our study was to evaluate the association between the mammographic appearance and the biologic characteristics of high-grade breast carcinomas. Three hundred and twenty patients with breast carcinomas were studied. Histological examination showed 83 (26%) high-grade ductal carcinomas. Immunohistochemistry was carried out by using antibodies against estrogen receptor (ER), progesterone receptor (PR), HER-2/neu, p53 and cathepsin D. In 60/83 high-grade carcinomas we studied the mammographic appearance. Asymmetric density with poorly defined margins without microcalcifications was the major mammographic finding in 49/60 (approximately 82%) high-grade ductal carcinomas. HER-2/neu positivity (68.7%) and p53 positivity (48.2%) were statistically correlated with asymmetric density with poorly defined margins without microcalcifications in high-grade carcinomas. We observed loss of ER and PR receptors in 50%, whereas loss of PR receptors was observed in 65% of high-grade breast carcinomas. Cathepsin D (> 20%) was detected in 38.5% of high-grade carcinomas. Our findings suggest a significant relationship between mammographic appearance and biologic markers in high-grade breast carcinomas.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Biopsy, Needle, Breast Neoplasms/genetics/*metabolism/*pathology, Carcinoma, Intraductal, Noninfiltrating/genetics/*metabolism/*pathology, Cathepsin D/metabolism, Cohort Studies, Female, *Gene Expression Regulation, Neoplastic, Genes, p53, Humans, Immunohistochemistry, *Mammography, Middle Aged, Molecular Biology, Neoplasm Staging, Prognosis, Proto-Oncogene Proteins c-bcl-2/metabolism, Receptor, erbB-2/metabolism, Receptors, Estrogen/metabolism, Receptors, Progesterone/analysis, Sensitivity and Specificity, Tumor Markers, Biological/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16550966
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής