Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas

Απλή σελίδα τεκμηρίου
dc.contributor.authorLikaki-Karatza, E.en
dc.contributor.authorRavazoula, P.en
dc.contributor.authorAndroutsopoulos, G. P.en
dc.contributor.authorMichail, G.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorTzorakoleftherakis, E.en
dc.contributor.authorKalofonos, H.en
dc.contributor.authorKourounis, G.en
dc.date.accessioned2015-11-24T19:26:47Z
dc.date.available2015-11-24T19:26:47Z
dc.identifier.issn0392-2936-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22758
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBiopsy, Needleen
dc.subjectBreast Neoplasms/genetics/*metabolism/*pathologyen
dc.subjectCarcinoma, Intraductal, Noninfiltrating/genetics/*metabolism/*pathologyen
dc.subjectCathepsin D/metabolismen
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectGenes, p53en
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subject*Mammographyen
dc.subjectMiddle Ageden
dc.subjectMolecular Biologyen
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectProto-Oncogene Proteins c-bcl-2/metabolismen
dc.subjectReceptor, erbB-2/metabolismen
dc.subjectReceptors, Estrogen/metabolismen
dc.subjectReceptors, Progesterone/analysisen
dc.subjectSensitivity and Specificityen
dc.subjectTumor Markers, Biological/analysisen
dc.titleCorrelation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomasen
heal.abstractThe aim of our study was to evaluate the association between the mammographic appearance and the biologic characteristics of high-grade breast carcinomas. Three hundred and twenty patients with breast carcinomas were studied. Histological examination showed 83 (26%) high-grade ductal carcinomas. Immunohistochemistry was carried out by using antibodies against estrogen receptor (ER), progesterone receptor (PR), HER-2/neu, p53 and cathepsin D. In 60/83 high-grade carcinomas we studied the mammographic appearance. Asymmetric density with poorly defined margins without microcalcifications was the major mammographic finding in 49/60 (approximately 82%) high-grade ductal carcinomas. HER-2/neu positivity (68.7%) and p53 positivity (48.2%) were statistically correlated with asymmetric density with poorly defined margins without microcalcifications in high-grade carcinomas. We observed loss of ER and PR receptors in 50%, whereas loss of PR receptors was observed in 65% of high-grade breast carcinomas. Cathepsin D (> 20%) was detected in 38.5% of high-grade carcinomas. Our findings suggest a significant relationship between mammographic appearance and biologic markers in high-grade breast carcinomas.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16550966-
heal.journalNameEur J Gynaecol Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ