Prothymosin alpha associates with the oncoprotein SET and is involved in chromatin decondensation

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dc.contributor.authorKaretsou, Z.en
dc.contributor.authorMartic, G.en
dc.contributor.authorTavoulari, S.en
dc.contributor.authorChristoforidis, S.en
dc.contributor.authorWilm, M.en
dc.contributor.authorGruss, C.en
dc.contributor.authorPapamarcaki, T.en
dc.date.accessioned2015-11-24T18:55:52Z
dc.date.available2015-11-24T18:55:52Z
dc.identifier.issn0014-5793-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18944
dc.rightsDefault Licence-
dc.subjectAmino Acid Sequenceen
dc.subjectBlotting, Westernen
dc.subjectCREB-Binding Proteinen
dc.subjectCell Extractsen
dc.subjectChromatin/*metabolismen
dc.subjectChromosomal Proteins, Non-Histoneen
dc.subjectGreen Fluorescent Proteins/metabolismen
dc.subjectHeLa Cellsen
dc.subjectHistone Chaperonesen
dc.subjectHumansen
dc.subjectLuciferases/metabolismen
dc.subjectMaleen
dc.subjectMass Spectrometryen
dc.subjectMolecular Sequence Dataen
dc.subjectMolecular Weighten
dc.subjectNuclear Proteins/metabolismen
dc.subjectPlasmids/metabolismen
dc.subjectPrecipitin Testsen
dc.subjectProtein Bindingen
dc.subjectProtein Precursors/genetics/*metabolismen
dc.subjectProteins/chemistry/*metabolismen
dc.subjectRecombinant Proteins/metabolismen
dc.subjectSequence Analysis, Proteinen
dc.subjectSilver Stainingen
dc.subjectSpermatozoa/metabolismen
dc.subjectThymosin/*analogs & derivatives/genetics/*metabolismen
dc.subjectTrans-Activators/metabolismen
dc.subjectTranscription Factorsen
dc.subjectTwo-Hybrid System Techniquesen
dc.titleProthymosin alpha associates with the oncoprotein SET and is involved in chromatin decondensationen
heal.abstractProthymosin alpha (ProTalpha) is a histone H1-binding protein that interacts with the transcription coactivator CREB-binding protein and potentiates transcription. Based on coimmunoprecipitation and mammalian two-hybrid assays, we show here that ProTalpha forms a complex with the oncoprotein SET. ProTalpha efficiently decondenses human sperm chromatin, while overexpression of GFP-ProTalpha in mammalian cells results in global chromatin decondensation. These results indicate that decondensation of compacted chromatin fibers is an important step in the mechanism of ProTalpha function.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.febslet.2004.09.091-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15556635-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0014579304013092/1-s2.0-S0014579304013092-main.pdf?_tid=5f5e3605208ca5324cba8a33ba040be6&acdnat=1332915888_a34e4db20aaf673ebf5d2d976d8aed0c-
heal.journalNameFEBS Letten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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