The relative value of metabolic syndrome and cardiovascular risk score estimates in premature acute coronary syndromes

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dc.contributor.authorKalantzi, K.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorTzimas, P.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorGoudevenos, J. A.en
dc.contributor.authorMilionis, H. J.en
dc.date.accessioned2015-11-24T19:32:15Z
dc.date.available2015-11-24T19:32:15Z
dc.identifier.issn1097-6744-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23387
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectCholesterol, LDL/blooden
dc.subjectCoronary Disease/diagnosis/epidemiology/*etiologyen
dc.subjectElectrocardiographyen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/blood/*complications/epidemiologyen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectPrognosisen
dc.subjectRetrospective Studiesen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectSyndromeen
dc.titleThe relative value of metabolic syndrome and cardiovascular risk score estimates in premature acute coronary syndromesen
heal.abstractBACKGROUND: To compare the relative value of metabolic syndrome (MetS) and cardiovascular risk score estimates in patients with acute coronary syndromes (ACS) aged <45 years. PATIENTS AND METHODS: Two hundred consecutive patients (183 men, mean age 40.8 +/- 3.5 years) presented with a first-ever ACS, and 200 age-and sex-matched controls were evaluated. Metabolic syndrome diagnostic criteria, European Risk SCORE estimation function, and the Framingham Risk Score (FRS) were assessed in all participants. RESULTS: The prevalence of the MetS was significantly higher in the patients' group compared with the control group (51.5% vs 26.0%, P < .001). No subjects with a SCORE >1.0% were identified. The mean 10-year FRS for patients and controls was 13.03% +/- 7.96% and 10.02 +/- 8.10%, respectively (P < .001), whereas only 22.5% of ACS patients had a 10-year risk >20.0% compared with 14.5% of controls (P = .04). After controlling for potential confounders, MetS was associated with 1.93 (95% CI 1.13-3.28, P = .01) higher odds of having an ACS. Moreover, the odds had a positive association with the increasing cumulative number of MetS components. Crude and adjusted ORs for the FRS were 1.05 (95% CI 1.029-1.08, P = .001) and 0.98 (95% CI 0.92-1.05, P = NS), respectively. CONCLUSION: Metabolic syndrome is highly associated with ACS in subjects <45 years of age and seems to be more valuable than established cardiovascular risk calculators.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ahj.2007.10.038-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18294493-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0002870307008770/1-s2.0-S0002870307008770-main.pdf?_tid=553ba1a9a7c18a493f9346c21890a9a3&acdnat=1333963188_b78839d62451badcf19abfdd31a42038-
heal.journalNameAm Heart Jen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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