Phenotypic assessment of Neisseria meningitidis isolates obtained from patients with invasive meningococcal disease in Greece, 1993-2003: implications for serogroup B vaccines based on PorA serosubtype antigens
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tzankaki, G.
Markou, F.
Kesanopoulos, K.
Levidiotou, S.
Pangalis, A.
Tsolia, M.
Liakou, V.
Papapavasiliou, E.
Voyiatzi, A.
Kansouzidou, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Vaccine
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Serogroup B is the major isolate from patients with invasive meningococcal disease (IMD) in Greece. This study used the whole cell enzyme-linked immuosorbent assay (ELISA) with monoclonal antibodies to screen Neisseria meningitidis isolates obtained from patients with IMD between 1993 and 2003 to determine if serosubtypes included in the hexavalent Por A OMP vaccines being tested in northern Europe were prevalent in Greece. During this period there were significant changes in the proportions of serogroups B and C isolated from patients. Serogroup C was predominant in 1996-1997 but fell sharply with corresponding increases in serogroup B. Of the 591 isolates sent to the National Meningitis Reference Laboratory in Athens during this period, 325 (55%) were serogroup B. Among those tested for serosubtype, porA proteins used for the vaccine being tested in Britain were detected on 85/284 (30%) strains and for the vaccine being tested in the Netherlands 175/284 (62%). P1.14 (58/284, 20%) the predominant serosubtype among the Greek isolates, is not present in either vaccine formulation; 23/284 (8%) strains did not react with any of the monoclonal antibodies. Our results indicate that introduction of the vaccines currently being evaluated in northern Europe would not be warranted in the Greek population.
Περιγραφή
Λέξεις-κλειδιά
Antigens, Bacterial/immunology, Bacterial Vaccines/*immunology, Greece, Humans, Meningitis, Bacterial/immunology/*microbiology/prevention & control, Neisseria meningitidis/*isolation & purification, Porins/classification/*immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16153759
http://ac.els-cdn.com/S0264410X05007346/1-s2.0-S0264410X05007346-main.pdf?_tid=c7df14285a9f4d7cca1586a0dc5fdd18&acdnat=1332827685_0c91e1609f5772a2cd93c6deb07a847b
http://ac.els-cdn.com/S0264410X05007346/1-s2.0-S0264410X05007346-main.pdf?_tid=c7df14285a9f4d7cca1586a0dc5fdd18&acdnat=1332827685_0c91e1609f5772a2cd93c6deb07a847b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής