Phenotypic assessment of Neisseria meningitidis isolates obtained from patients with invasive meningococcal disease in Greece, 1993-2003: implications for serogroup B vaccines based on PorA serosubtype antigens

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dc.contributor.authorTzankaki, G.en
dc.contributor.authorMarkou, F.en
dc.contributor.authorKesanopoulos, K.en
dc.contributor.authorLevidiotou, S.en
dc.contributor.authorPangalis, A.en
dc.contributor.authorTsolia, M.en
dc.contributor.authorLiakou, V.en
dc.contributor.authorPapapavasiliou, E.en
dc.contributor.authorVoyiatzi, A.en
dc.contributor.authorKansouzidou, A.en
dc.contributor.authorFoustoukou, M.en
dc.contributor.authorBlackwell, C.en
dc.contributor.authorKremastinou, J.en
dc.date.accessioned2015-11-24T18:58:44Z
dc.date.available2015-11-24T18:58:44Z
dc.identifier.issn0264-410X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19306
dc.rightsDefault Licence-
dc.subjectAntigens, Bacterial/immunologyen
dc.subjectBacterial Vaccines/*immunologyen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectMeningitis, Bacterial/immunology/*microbiology/prevention & controlen
dc.subjectNeisseria meningitidis/*isolation & purificationen
dc.subjectPorins/classification/*immunologyen
dc.titlePhenotypic assessment of Neisseria meningitidis isolates obtained from patients with invasive meningococcal disease in Greece, 1993-2003: implications for serogroup B vaccines based on PorA serosubtype antigensen
heal.abstractSerogroup B is the major isolate from patients with invasive meningococcal disease (IMD) in Greece. This study used the whole cell enzyme-linked immuosorbent assay (ELISA) with monoclonal antibodies to screen Neisseria meningitidis isolates obtained from patients with IMD between 1993 and 2003 to determine if serosubtypes included in the hexavalent Por A OMP vaccines being tested in northern Europe were prevalent in Greece. During this period there were significant changes in the proportions of serogroups B and C isolated from patients. Serogroup C was predominant in 1996-1997 but fell sharply with corresponding increases in serogroup B. Of the 591 isolates sent to the National Meningitis Reference Laboratory in Athens during this period, 325 (55%) were serogroup B. Among those tested for serosubtype, porA proteins used for the vaccine being tested in Britain were detected on 85/284 (30%) strains and for the vaccine being tested in the Netherlands 175/284 (62%). P1.14 (58/284, 20%) the predominant serosubtype among the Greek isolates, is not present in either vaccine formulation; 23/284 (8%) strains did not react with any of the monoclonal antibodies. Our results indicate that introduction of the vaccines currently being evaluated in northern Europe would not be warranted in the Greek population.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.vaccine.2005.07.058-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16153759-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0264410X05007346/1-s2.0-S0264410X05007346-main.pdf?_tid=c7df14285a9f4d7cca1586a0dc5fdd18&acdnat=1332827685_0c91e1609f5772a2cd93c6deb07a847b-
heal.journalNameVaccineen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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