Paraoxonase gene polymorphisms and stroke severity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Lazaros, L.
Markoula, S.
Kyritsis, A.
Georgiou, I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Neurol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Paraoxonase (PON) is an HDL-associated enzyme that prevents low-density lipoprotein oxidation, playing a major role in the pathogenesis of atherosclerosis. PON genes polymorphisms may affect the corresponding enzyme activity. In this study, we examined the association of ischemic stroke with the three PON genes. METHODS: One hundred and seventy-eight patients hospitalized for ischemic stroke and 181 age- and sex-matched healthy controls were recruited. PON1(Q/R) 192, PON1(M/L) 55, and PON2(S/C) 311 polymorphisms were analyzed. RESULTS: The presence of the PON2 311C allele was significantly increased in patients with severe forms of ischemic stroke according to Modified Rankin Scale (P = 0.02, odds ratio = 2.215). No significant differences in genotype and allele distribution were observed between patients and controls. CONCLUSIONS: The PON2 311C allele was suggested as a possible predisposing factor for severe cases of ischemic stroke. Large-scale multicenter-controlled prospective studies are warranted to further explore the effects of PON polymorphisms on stroke susceptibility and severity.
Περιγραφή
Λέξεις-κλειδιά
Aged, Aryldialkylphosphatase/*genetics, Atherosclerosis/enzymology/genetics, Brain Ischemia/enzymology/genetics, Cohort Studies, Female, Gene Frequency/genetics, Genetic Markers/genetics, Genetic Predisposition to Disease/genetics, Genetic Testing, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic/*genetics, *Severity of Illness Index, Stroke/*enzymology/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19930448
http://onlinelibrary.wiley.com/store/10.1111/j.1468-1331.2009.02860.x/asset/j.1468-1331.2009.02860.x.pdf?v=1&t=h0j4l568&s=ea767cd675e0435294b1bbad35fcba3624ff2722
http://onlinelibrary.wiley.com/store/10.1111/j.1468-1331.2009.02860.x/asset/j.1468-1331.2009.02860.x.pdf?v=1&t=h0j4l568&s=ea767cd675e0435294b1bbad35fcba3624ff2722
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής