Evaluation of six tumor markers in patients with carcinoma of unknown primary
Φόρτωση...
Ημερομηνία
Συγγραφείς
Pavlidis, N.
Kalef-Ezra, J.
Briassoulis, E.
Skarlos, D.
Kosmidis, P.
Saferiadis, K.
Bairaktari, E.
Bafaloukos, D.
Maravegias, A.
Theoharis, D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Med Pediatr Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
We have retrospectively evaluated six serum tumor markers in 85 patients with carcinoma of unknown primary. The serum levels of carcinoembryonic antigen (CEA), CA 19-9, CA 15-3, CA 125, beta-chorionic gonadotropin (beta-HCG) and alpha-fetoprotein (AFP) were related with the histological pattern (undifferentiated carcinoma or adenocarcinoma), the number and the site of metastases, as well as the response to chemotherapy and the patients' survival. More than 40% of the patients had increased serum levels of all six tumor markers, except of AFP which was found to be increased in only 17% of them. Increased levels of CA 19-9 were related to metastatic adenocarcinoma, whereas CA 19-9 and CA 15-3 had a relationship with more advanced disease. Patients with liver involvement had higher mean levels of CEA and CA 19-9 as compared to those with nodal disease. None of these markers was found to have a predictive value for response to chemotherapy or survival. Although the present study has a retrospective nature, it allows us to conclude that patients with CUP have a nonspecific over-expression of the above serum tumor markers and that routine use of these markers does not offer any diagnostic or prognostic assistance.
Περιγραφή
Λέξεις-κλειδιά
Adenocarcinoma/secondary, Adult, Antigens, Neoplasm/*blood, Antigens, Tumor-Associated, Carbohydrate/blood, Bone Neoplasms/secondary, Carcinoembryonic Antigen/blood, Carcinoma/secondary, Central Nervous System Neoplasms/secondary, Chorionic Gonadotropin/blood, Female, Humans, Linear Models, Liver Neoplasms/secondary, Lung Neoplasms/secondary, Lymph Nodes, Male, Middle Aged, Neoplasms, Unknown Primary/*blood/drug therapy/mortality, Peritoneal Neoplasms/secondary, Predictive Value of Tests, Retrospective Studies, Survival Rate, Tumor Markers, Biological/*blood, alpha-Fetoproteins/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/7505876
http://onlinelibrary.wiley.com/store/10.1002/mpo.2950220303/asset/2950220303_ftp.pdf?v=1&t=h0ant4gk&s=6cddb224b324af784c141d148525a259fdcff1bb
http://onlinelibrary.wiley.com/store/10.1002/mpo.2950220303/asset/2950220303_ftp.pdf?v=1&t=h0ant4gk&s=6cddb224b324af784c141d148525a259fdcff1bb
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής