Evaluation of six tumor markers in patients with carcinoma of unknown primary

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dc.contributor.authorPavlidis, N.en
dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorBriassoulis, E.en
dc.contributor.authorSkarlos, D.en
dc.contributor.authorKosmidis, P.en
dc.contributor.authorSaferiadis, K.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorBafaloukos, D.en
dc.contributor.authorMaravegias, A.en
dc.contributor.authorTheoharis, D.en
dc.contributor.authoret al.,en
dc.date.accessioned2015-11-24T19:17:43Z
dc.date.available2015-11-24T19:17:43Z
dc.identifier.issn0098-1532-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21803
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/secondaryen
dc.subjectAdulten
dc.subjectAntigens, Neoplasm/*blooden
dc.subjectAntigens, Tumor-Associated, Carbohydrate/blooden
dc.subjectBone Neoplasms/secondaryen
dc.subjectCarcinoembryonic Antigen/blooden
dc.subjectCarcinoma/secondaryen
dc.subjectCentral Nervous System Neoplasms/secondaryen
dc.subjectChorionic Gonadotropin/blooden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectLiver Neoplasms/secondaryen
dc.subjectLung Neoplasms/secondaryen
dc.subjectLymph Nodesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasms, Unknown Primary/*blood/drug therapy/mortalityen
dc.subjectPeritoneal Neoplasms/secondaryen
dc.subjectPredictive Value of Testsen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Rateen
dc.subjectTumor Markers, Biological/*blooden
dc.subjectalpha-Fetoproteins/analysisen
dc.titleEvaluation of six tumor markers in patients with carcinoma of unknown primaryen
heal.abstractWe have retrospectively evaluated six serum tumor markers in 85 patients with carcinoma of unknown primary. The serum levels of carcinoembryonic antigen (CEA), CA 19-9, CA 15-3, CA 125, beta-chorionic gonadotropin (beta-HCG) and alpha-fetoprotein (AFP) were related with the histological pattern (undifferentiated carcinoma or adenocarcinoma), the number and the site of metastases, as well as the response to chemotherapy and the patients' survival. More than 40% of the patients had increased serum levels of all six tumor markers, except of AFP which was found to be increased in only 17% of them. Increased levels of CA 19-9 were related to metastatic adenocarcinoma, whereas CA 19-9 and CA 15-3 had a relationship with more advanced disease. Patients with liver involvement had higher mean levels of CEA and CA 19-9 as compared to those with nodal disease. None of these markers was found to have a predictive value for response to chemotherapy or survival. Although the present study has a retrospective nature, it allows us to conclude that patients with CUP have a nonspecific over-expression of the above serum tumor markers and that routine use of these markers does not offer any diagnostic or prognostic assistance.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7505876-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/mpo.2950220303/asset/2950220303_ftp.pdf?v=1&t=h0ant4gk&s=6cddb224b324af784c141d148525a259fdcff1bb-
heal.journalNameMed Pediatr Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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