Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients
Φόρτωση...
Ημερομηνία
Συγγραφείς
Manousou, P.
Kalambokis, G.
Grillo, F.
Watkins, J.
Xirouchakis, E.
Pleguezuelo, M.
Leandro, G.
Arvaniti, V.
Germani, G.
Patch, D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Liver Int
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
INTRODUCTION: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in non-alcoholic fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either to diagnose NASH or to select patients for liver biopsy. PATIENTS AND METHODS: We evaluated serum ferritin and the features of metabolic syndrome with respect to histological inflammation and/or fibrosis in NAFLD patients. The Kleiner scoring system was used to classify NAFLD in consecutive liver biopsies. One hundred and eleven patients: median age 52.6, 64 males, obesity 62, diabetes mellitus (DM) 58, arterial hypertension 26 and hyperlipidaemia 40%. RESULTS: Histologically, 40.7 had fatty liver, 30.6% had borderline NASH, 28.7% had NASH and 11% had cirrhosis. Multivariate regression showed that diabetes, serum ferritin concentrations, body mass index (BMI) and AST were independently associated with NASH: together, the areas under the receiver operating characteristic (AUROC) was 0.91 (95% confidence interval 0.86-0.96); fibrosis was associated with ferritin concentrations and BMI: AUROC 0.87, portal inflammation with ferritin and DM: AUROC 0.82, while lobular inflammation was associated with BMI, DM and ferritin: AUROC 0.85. CONCLUSION: Serum ferritin concentrations and BMI are strongly associated with fibrosis, portal and lobular inflammation in NAFLD patients. Both ferritin and BMI are potential discriminant markers to select patients for liver biopsy and are associated with inflammation and fibrosis.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aspartate Aminotransferases/blood, Biological Markers/blood, Biopsy, Body Mass Index, Chi-Square Distribution, Diabetes Complications/blood/diagnosis/etiology, Fatty Liver/blood/diagnosis/etiology/pathology, Female, Ferritins/*blood, Hepatitis/blood/complications/*diagnosis, Humans, Hyperlipidemias/blood/complications, Hypertension/blood/complications, Liver Cirrhosis/blood/*diagnosis/etiology, Logistic Models, London, Male, Metabolic Syndrome X/blood/*complications, Middle Aged, Nomograms, Obesity/complications, Patient Selection, Predictive Value of Tests, Risk Assessment, Risk Factors, Severity of Illness Index, Young Adult
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21457446
http://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2011.02488.x/asset/j.1478-3231.2011.02488.x.pdf?v=1&t=h0ulyrpm&s=7a793e3f28bcd986b103095ac628737b20dbe921
http://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2011.02488.x/asset/j.1478-3231.2011.02488.x.pdf?v=1&t=h0ulyrpm&s=7a793e3f28bcd986b103095ac628737b20dbe921
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής