Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients

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dc.contributor.authorManousou, P.en
dc.contributor.authorKalambokis, G.en
dc.contributor.authorGrillo, F.en
dc.contributor.authorWatkins, J.en
dc.contributor.authorXirouchakis, E.en
dc.contributor.authorPleguezuelo, M.en
dc.contributor.authorLeandro, G.en
dc.contributor.authorArvaniti, V.en
dc.contributor.authorGermani, G.en
dc.contributor.authorPatch, D.en
dc.contributor.authorCalvaruso, V.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorDhillon, A. P.en
dc.contributor.authorBurroughs, A. K.en
dc.date.accessioned2015-11-24T18:52:11Z
dc.date.available2015-11-24T18:52:11Z
dc.identifier.issn1478-3231-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18366
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAspartate Aminotransferases/blooden
dc.subjectBiological Markers/blooden
dc.subjectBiopsyen
dc.subjectBody Mass Indexen
dc.subjectChi-Square Distributionen
dc.subjectDiabetes Complications/blood/diagnosis/etiologyen
dc.subjectFatty Liver/blood/diagnosis/etiology/pathologyen
dc.subjectFemaleen
dc.subjectFerritins/*blooden
dc.subjectHepatitis/blood/complications/*diagnosisen
dc.subjectHumansen
dc.subjectHyperlipidemias/blood/complicationsen
dc.subjectHypertension/blood/complicationsen
dc.subjectLiver Cirrhosis/blood/*diagnosis/etiologyen
dc.subjectLogistic Modelsen
dc.subjectLondonen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/blood/*complicationsen
dc.subjectMiddle Ageden
dc.subjectNomogramsen
dc.subjectObesity/complicationsen
dc.subjectPatient Selectionen
dc.subjectPredictive Value of Testsen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectSeverity of Illness Indexen
dc.subjectYoung Adulten
dc.titleSerum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patientsen
heal.abstractINTRODUCTION: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in non-alcoholic fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either to diagnose NASH or to select patients for liver biopsy. PATIENTS AND METHODS: We evaluated serum ferritin and the features of metabolic syndrome with respect to histological inflammation and/or fibrosis in NAFLD patients. The Kleiner scoring system was used to classify NAFLD in consecutive liver biopsies. One hundred and eleven patients: median age 52.6, 64 males, obesity 62, diabetes mellitus (DM) 58, arterial hypertension 26 and hyperlipidaemia 40%. RESULTS: Histologically, 40.7 had fatty liver, 30.6% had borderline NASH, 28.7% had NASH and 11% had cirrhosis. Multivariate regression showed that diabetes, serum ferritin concentrations, body mass index (BMI) and AST were independently associated with NASH: together, the areas under the receiver operating characteristic (AUROC) was 0.91 (95% confidence interval 0.86-0.96); fibrosis was associated with ferritin concentrations and BMI: AUROC 0.87, portal inflammation with ferritin and DM: AUROC 0.82, while lobular inflammation was associated with BMI, DM and ferritin: AUROC 0.85. CONCLUSION: Serum ferritin concentrations and BMI are strongly associated with fibrosis, portal and lobular inflammation in NAFLD patients. Both ferritin and BMI are potential discriminant markers to select patients for liver biopsy and are associated with inflammation and fibrosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1478-3231.2011.02488.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21457446-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2011.02488.x/asset/j.1478-3231.2011.02488.x.pdf?v=1&t=h0ulyrpm&s=7a793e3f28bcd986b103095ac628737b20dbe921-
heal.journalNameLiver Inten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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