Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Ioannidis, J. P.
Stavrou, I.
Trikalinos, T. A.
Zois, C.
Brandi, M. L.
Gennari, L.
Albagha, O.
Ralston, S. H.
Tsatsoulis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Bone Miner Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The contribution of genetic polymorphisms to bone mineral density (BMD) and fracture risk in women is a controversial topic. We evaluated the effect of the XbaI and PvuII polymorphisms of the estrogen receptor a to BMD and fracture risk in a meta-analysis, including published data and additional information from investigators. Five thousand eight hundred thirty-four women from 30 study groups were analyzed with fixed and random effects models. The PvuII polymorphism was not associated with BMD at any skeletal site examined and 95% CIs exclude effects over 0.015 g/cm2 for both the femoral neck and the lumbar spine. Conversely, XX homozygotes (women carrying two copies of the gene variant without an XbaI restriction site) consistently had higher BMD than other subjects. The magnitude of the effect was similar in the femoral neck and lumbar spine (0.014 g/cm2 [95% CI, 0.003-0.025] and 0.015 g/cm2 [95% CI, 0.000-0.030], respectively; no between-study heterogeneity for either). Total body BMD was also significantly higher in XX homozygotes (by 0.039 g/cm2 and 0.029 g/cm2 compared with Xx and xx, respectively). Available data on fractures suggested a protective effect for XX (odds ratio [OR], 0.66 [95% CI, 0.47-0.93] among 1591 women), but not PP (OR, 0.93 [95% CI, 0.72-1.18] among 2,229 women). In summary, we have found that XX homozygotes may have higher BMD and also a decreased risk of fractures when compared with carriers of the x allele, whereas the PvuII polymorphism is not associated with either BMD or fracture risk.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Alleles, Bone Density/*genetics, Deoxyribonucleases, Type II Site-Specific/genetics, Estrogen Receptor alpha, Female, Femur/physiology, Fractures, Bone/*genetics, Gene Frequency, Genetic Predisposition to Disease, Homozygote, Humans, Lumbar Vertebrae/physiology, Middle Aged, Odds Ratio, *Polymorphism, Genetic, Receptors, Estrogen/*genetics, Risk Assessment
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12412813
http://onlinelibrary.wiley.com/store/10.1359/jbmr.2002.17.11.2048/asset/5650171118_ftp.pdf?v=1&t=h0jepje4&s=109fefd718d96e6bfca4d5df7581cebf508b67d6
http://onlinelibrary.wiley.com/store/10.1359/jbmr.2002.17.11.2048/asset/5650171118_ftp.pdf?v=1&t=h0jepje4&s=109fefd718d96e6bfca4d5df7581cebf508b67d6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής