Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorStavrou, I.en
dc.contributor.authorTrikalinos, T. A.en
dc.contributor.authorZois, C.en
dc.contributor.authorBrandi, M. L.en
dc.contributor.authorGennari, L.en
dc.contributor.authorAlbagha, O.en
dc.contributor.authorRalston, S. H.en
dc.contributor.authorTsatsoulis, A.en
dc.date.accessioned2015-11-24T19:34:44Z
dc.date.available2015-11-24T19:34:44Z
dc.identifier.issn0884-0431-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23647
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAllelesen
dc.subjectBone Density/*geneticsen
dc.subjectDeoxyribonucleases, Type II Site-Specific/geneticsen
dc.subjectEstrogen Receptor alphaen
dc.subjectFemaleen
dc.subjectFemur/physiologyen
dc.subjectFractures, Bone/*geneticsen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectLumbar Vertebrae/physiologyen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subject*Polymorphism, Geneticen
dc.subjectReceptors, Estrogen/*geneticsen
dc.subjectRisk Assessmenten
dc.titleAssociation of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysisen
heal.abstractThe contribution of genetic polymorphisms to bone mineral density (BMD) and fracture risk in women is a controversial topic. We evaluated the effect of the XbaI and PvuII polymorphisms of the estrogen receptor a to BMD and fracture risk in a meta-analysis, including published data and additional information from investigators. Five thousand eight hundred thirty-four women from 30 study groups were analyzed with fixed and random effects models. The PvuII polymorphism was not associated with BMD at any skeletal site examined and 95% CIs exclude effects over 0.015 g/cm2 for both the femoral neck and the lumbar spine. Conversely, XX homozygotes (women carrying two copies of the gene variant without an XbaI restriction site) consistently had higher BMD than other subjects. The magnitude of the effect was similar in the femoral neck and lumbar spine (0.014 g/cm2 [95% CI, 0.003-0.025] and 0.015 g/cm2 [95% CI, 0.000-0.030], respectively; no between-study heterogeneity for either). Total body BMD was also significantly higher in XX homozygotes (by 0.039 g/cm2 and 0.029 g/cm2 compared with Xx and xx, respectively). Available data on fractures suggested a protective effect for XX (odds ratio [OR], 0.66 [95% CI, 0.47-0.93] among 1591 women), but not PP (OR, 0.93 [95% CI, 0.72-1.18] among 2,229 women). In summary, we have found that XX homozygotes may have higher BMD and also a decreased risk of fractures when compared with carriers of the x allele, whereas the PvuII polymorphism is not associated with either BMD or fracture risk.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1359/jbmr.2002.17.11.2048-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12412813-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1359/jbmr.2002.17.11.2048/asset/5650171118_ftp.pdf?v=1&t=h0jepje4&s=109fefd718d96e6bfca4d5df7581cebf508b67d6-
heal.journalNameJ Bone Miner Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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