Plasma inhibin levels in men with chemotherapy-induced severe damage to the seminiferous epithelium
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Endocrinol (Oxf)
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Immunoreactive plasma inhibin levels and free testosterone index (FTI) were estimated in 17 patients who had previously received combination chemotherapy for Hodgkin's disease and in 16 age-matched controls. In the same patients we had previously found significantly raised FSH and LH levels in the presence of normal basal and HCG-stimulated total testosterone levels. Mean plasma inhibin levels were not different between the patients (601 +/- 321 U/l) and controls (530 +/- 174 U/l) nor were FTI values (81.5 +/- 35 vs 91 +/- 47 respectively). There was a positive correlation (r = 0.53, P less than 0.05) between FSH and inhibin levels and a negative correlation between FSH and FTI (r = -0.51, P less than 0.05) in the patients but not in the controls. No such correlations with inhibin or FTI existed for LH but there was a positive correlation between LH and FSH levels in the patients. In four patients inhibin levels were pathologically raised and in this group mean FSH values (21.7 +/- 4.7 IU/l) were higher (P less than 0.001) and mean FTI (59.1 +/- 22.6) lower (P less than 0.001) than respective values (13.6 +/- 5.3 IU/l and 88.4 +/- 35) for the remainder of the patients. These data are not compatible with the hypothesis that inhibin is the major negative feedback signal for the control of FSH secretion.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols/*adverse effects, Follicle Stimulating Hormone/blood, Hodgkin Disease/drug therapy, Humans, Inhibins/*blood, Male, Mechlorethamine/adverse effects, Prednisolone/adverse effects, Procarbazine/adverse effects, Seminiferous Epithelium/*drug effects, Testis/*drug effects, Testosterone/blood, Vinblastine/adverse effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/3151478
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1988.tb03714.x/asset/j.1365-2265.1988.tb03714.x.pdf?v=1&t=h0ouslxt&s=5c685e9ca34161d7d088c5c43a215b2f22f7701c
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1988.tb03714.x/asset/j.1365-2265.1988.tb03714.x.pdf?v=1&t=h0ouslxt&s=5c685e9ca34161d7d088c5c43a215b2f22f7701c
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής