Plasma inhibin levels in men with chemotherapy-induced severe damage to the seminiferous epithelium
| dc.contributor.author | Tsatsoulis, A. | en |
| dc.contributor.author | Shalet, S. M. | en |
| dc.contributor.author | Robertson, W. R. | en |
| dc.contributor.author | Morris, I. D. | en |
| dc.contributor.author | Burger, H. G. | en |
| dc.contributor.author | De Kretser, D. M. | en |
| dc.date.accessioned | 2015-11-24T18:58:16Z | |
| dc.date.available | 2015-11-24T18:58:16Z | |
| dc.identifier.issn | 0300-0664 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19263 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Antineoplastic Combined Chemotherapy Protocols/*adverse effects | en |
| dc.subject | Follicle Stimulating Hormone/blood | en |
| dc.subject | Hodgkin Disease/drug therapy | en |
| dc.subject | Humans | en |
| dc.subject | Inhibins/*blood | en |
| dc.subject | Male | en |
| dc.subject | Mechlorethamine/adverse effects | en |
| dc.subject | Prednisolone/adverse effects | en |
| dc.subject | Procarbazine/adverse effects | en |
| dc.subject | Seminiferous Epithelium/*drug effects | en |
| dc.subject | Testis/*drug effects | en |
| dc.subject | Testosterone/blood | en |
| dc.subject | Vinblastine/adverse effects | en |
| dc.title | Plasma inhibin levels in men with chemotherapy-induced severe damage to the seminiferous epithelium | en |
| heal.abstract | Immunoreactive plasma inhibin levels and free testosterone index (FTI) were estimated in 17 patients who had previously received combination chemotherapy for Hodgkin's disease and in 16 age-matched controls. In the same patients we had previously found significantly raised FSH and LH levels in the presence of normal basal and HCG-stimulated total testosterone levels. Mean plasma inhibin levels were not different between the patients (601 +/- 321 U/l) and controls (530 +/- 174 U/l) nor were FTI values (81.5 +/- 35 vs 91 +/- 47 respectively). There was a positive correlation (r = 0.53, P less than 0.05) between FSH and inhibin levels and a negative correlation between FSH and FTI (r = -0.51, P less than 0.05) in the patients but not in the controls. No such correlations with inhibin or FTI existed for LH but there was a positive correlation between LH and FSH levels in the patients. In four patients inhibin levels were pathologically raised and in this group mean FSH values (21.7 +/- 4.7 IU/l) were higher (P less than 0.001) and mean FTI (59.1 +/- 22.6) lower (P less than 0.001) than respective values (13.6 +/- 5.3 IU/l and 88.4 +/- 35) for the remainder of the patients. These data are not compatible with the hypothesis that inhibin is the major negative feedback signal for the control of FSH secretion. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3151478 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1988.tb03714.x/asset/j.1365-2265.1988.tb03714.x.pdf?v=1&t=h0ouslxt&s=5c685e9ca34161d7d088c5c43a215b2f22f7701c | - |
| heal.journalName | Clin Endocrinol (Oxf) | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1988 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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