Allergens responsible for allergic contact dermatitis among children: a systematic review and meta-analysis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Contact Dermatitis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Multiple studies have evaluated diverse allergens in paediatric populations. Consensus is still lacking on which allergens are most commonly implicated in allergic contact dermatitis. OBJECTIVES: To evaluate the proportion of positive reactions for allergens tested in children and to identify allergens with positive reactions in at least 1% of them. METHODS: This was a systematic review of studies in PubMed (1966-2010) investigating allergens in at least 100 enrolled children. Proportions of positive reactions for each allergen were combined with random effects models across studies. RESULTS: We included 49 studies with available data on 170 allergens. Each study tested a median of two allergens. Among the 94 allergens evaluated by at least two studies, 58 had estimates of positive reactions of at least 1% by random effects calculations, and for 21 of them the 95% confidence interval ensured that the proportion of positive reactions was at least 1%. The top five allergens tested by at least two studies included nickel sulfate, ammonium persulfate, gold sodium thiosulfate, thimerosal, and toluene-2,5-diamine (p-toluenediamine). For most allergens, the proportion of positive reactions was higher in studies published after 1995 than in earlier studies (p = 0.0065). CONCLUSIONS: This meta-analysis offers guidance on which allergens are most prevalent in the paediatric population and should have priority for inclusion in standardized allergen series.
Περιγραφή
Λέξεις-κλειδιά
Allergens/*adverse effects/immunology, Child, Dermatitis, Allergic Contact/*etiology, Humans, Patch Tests
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21480911
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0536.2010.01860.x/asset/j.1600-0536.2010.01860.x.pdf?v=1&t=h0je0k5e&s=25fe129c1198d76cd2c11381dc2b91e1e8512c64
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0536.2010.01860.x/asset/j.1600-0536.2010.01860.x.pdf?v=1&t=h0je0k5e&s=25fe129c1198d76cd2c11381dc2b91e1e8512c64
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής