Aspartyl methyl ester formation via aspartimide ring opening: a proposed modification of the protocols used in Boc- and Fmoc-based solid-phase peptide synthesis

Απλή σελίδα τεκμηρίου
dc.contributor.authorKostidis, S.en
dc.contributor.authorStathopoulos, P.en
dc.contributor.authorChondrogiannis, N. I.en
dc.contributor.authorSakarellos, C.en
dc.contributor.authorTsikaris, V.en
dc.date.accessioned2015-11-24T16:52:48Z
dc.date.available2015-11-24T16:52:48Z
dc.identifier.issn0040-4039-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9926
dc.rightsDefault Licence-
dc.subjectaspartimideen
dc.subjectalpha-, beta-aspartyl peptidesen
dc.subjectsolid-phase protocolsen
dc.subjectpeptide synthesis protocolsen
dc.subjectspps protocolsen
dc.subjectalpha-, beta-aspartyl methyl estersen
dc.subjectside reactionsen
dc.subjectprotecting groupen
dc.subjectaciden
dc.subjectsequenceen
dc.titleAspartyl methyl ester formation via aspartimide ring opening: a proposed modification of the protocols used in Boc- and Fmoc-based solid-phase peptide synthesisen
heal.abstractAspartimide formation is still an unresolved problem in the solid-phase peptide synthesis of aspartic acid-containing peptides, following either Boc- or Fmoc-based synthetic strategies. alpha-Aspartyl peptides of high purity can be obtained, despite aspartimide formation, by incorporating an additional step in the Boc- and Fmoc-based solid-phase peptide synthesis protocols, consisting of treatment of the peptide-resin with methanol in the presence of 2% DIEA (v/v) for 15 min immediately after completion of the peptide chain elongation. (C) 2003 Elsevier Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.tetlet.2003.09.163-
heal.identifier.secondary<Go to ISI>://000186474400009-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0040403903022974/1-s2.0-S0040403903022974-main.pdf?_tid=235a2e116a177147d30bd90274b02c2e&acdnat=1333112554_f421c3a3f2fbeecb5c96f4a5c0387728-
heal.journalNameTetrahedron Letten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ