Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis
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Authors
Voulgari, P. V.
Kolios, G.
Papadopoulos, G. K.
Katsaraki, A.
Seferiadis, K.
Drosos, A. A.
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peer-reviewed
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Clin Immunol
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Description
The aim of our study was to evaluate the role of proinflammatory cytokines: tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as the possible contribution of interleukin-10 (IL-10) in anemia of chronic disease (ACD) of rheumatoid arthritis (RA) patients. We measured the serum levels of TNFalpha, IL-1beta, and IL-6 in 105 anemic and 127 nonanemic RA patients. We also investigated the effects of the above cytokines on the development of burst-forming units-erythroid (BFUe) and colony-forming units-erythroid (CFUe) in bone marrow cultures. Anemic patients had significantly higher serum levels of TNFalpha, IL-1beta, and IL-6 compared to nonanemics. Serum IL-10 levels were low and there was no significant difference in IL-10 concentrations between anemic and nonanemic patients. Proinflammatory cytokines inhibited proliferation of BFUe and CFUe. IL-10 did not decrease the erythroid colony growth. Proinflammatory cytokines may play a role in the pathogenesis of ACD in RA patients. Low levels of IL-10 possibly contribute to the development of ACD.
Description
Keywords
Anemia/blood/*immunology/physiopathology, Arthritis, Rheumatoid/blood/*immunology/physiopathology, Bone Marrow Cells/cytology/drug effects, Cells, Cultured, Chronic Disease, Female, Humans, Interleukin-1/blood/*immunology/pharmacology, Interleukin-10/blood/*immunology/pharmacology, Interleukin-6/blood/*immunology/pharmacology, Male, Middle Aged, Tumor Necrosis Factor-alpha/*immunology/pharmacology
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http://www.ncbi.nlm.nih.gov/pubmed/10444359
http://ac.els-cdn.com/S1521661699947368/1-s2.0-S1521661699947368-main.pdf?_tid=a8814131f05ce8362daa4caf177e4920&acdnat=1333527103_bd0bd90106c0c3d189e9b0d9a87c73e6
http://ac.els-cdn.com/S1521661699947368/1-s2.0-S1521661699947368-main.pdf?_tid=a8814131f05ce8362daa4caf177e4920&acdnat=1333527103_bd0bd90106c0c3d189e9b0d9a87c73e6
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής