Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis
| dc.contributor.author | Voulgari, P. V. | en |
| dc.contributor.author | Kolios, G. | en |
| dc.contributor.author | Papadopoulos, G. K. | en |
| dc.contributor.author | Katsaraki, A. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.date.accessioned | 2015-11-24T18:53:14Z | |
| dc.date.available | 2015-11-24T18:53:14Z | |
| dc.identifier.issn | 1521-6616 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18522 | |
| dc.rights | Default Licence | - |
| dc.subject | Anemia/blood/*immunology/physiopathology | en |
| dc.subject | Arthritis, Rheumatoid/blood/*immunology/physiopathology | en |
| dc.subject | Bone Marrow Cells/cytology/drug effects | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Chronic Disease | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Interleukin-1/blood/*immunology/pharmacology | en |
| dc.subject | Interleukin-10/blood/*immunology/pharmacology | en |
| dc.subject | Interleukin-6/blood/*immunology/pharmacology | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Tumor Necrosis Factor-alpha/*immunology/pharmacology | en |
| dc.title | Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis | en |
| heal.abstract | The aim of our study was to evaluate the role of proinflammatory cytokines: tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as the possible contribution of interleukin-10 (IL-10) in anemia of chronic disease (ACD) of rheumatoid arthritis (RA) patients. We measured the serum levels of TNFalpha, IL-1beta, and IL-6 in 105 anemic and 127 nonanemic RA patients. We also investigated the effects of the above cytokines on the development of burst-forming units-erythroid (BFUe) and colony-forming units-erythroid (CFUe) in bone marrow cultures. Anemic patients had significantly higher serum levels of TNFalpha, IL-1beta, and IL-6 compared to nonanemics. Serum IL-10 levels were low and there was no significant difference in IL-10 concentrations between anemic and nonanemic patients. Proinflammatory cytokines inhibited proliferation of BFUe and CFUe. IL-10 did not decrease the erythroid colony growth. Proinflammatory cytokines may play a role in the pathogenesis of ACD in RA patients. Low levels of IL-10 possibly contribute to the development of ACD. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1006/clim.1999.4736 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10444359 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S1521661699947368/1-s2.0-S1521661699947368-main.pdf?_tid=a8814131f05ce8362daa4caf177e4920&acdnat=1333527103_bd0bd90106c0c3d189e9b0d9a87c73e6 | - |
| heal.journalName | Clin Immunol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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