Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological study
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Zartilas, S.
Hadjikakou, S. K.
Hadjiliadis, N.
Kourkoumelis, N.
Kyros, L.
Kubicki, M.
Baril, M.
Butler, I. S.
Karkabounas, S.
Balzarini, J.
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Elsevier
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peer reviewed
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Inorganica Chimica Acta
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Silver(I) halides react with tri(p-tolyl) phosphine (tptp, C(21)H(21)P) in MeOH/MeCN solutions in 1: 1 or 1: 3 molar ratios to give complexes of formulae {[AgCl(tptp)](4)} (1) or [AgX(tptp)(3)] (X = Cl (2), Br (3), I (4)), respectively. The complexes were characterized by elemental analyses, and FT-IR far-IR, FT-Raman, TG and (1)H, (13)C, (31)P NMR spectroscopic techniques. Crystal structures of complexes 2-4 were determined by X-ray diffraction at room temperature (rt). The crystal structure of 1 and 4 was also determined at 100(1) and 140(2) K (lt), respectively. In complex 1 four mu 3-Cl ions are bonded with four Ag(I) ions forming a cubane while the coordination sphere of silver(I) ions is completed by one P atom from a terminal tri(p-tolyl) phosphine ligand. In complexes 2-3 one terminal halogen and three P atoms from phosphine ligands form a tetrahedral arrangement around the metal ion. Complexes 1-4 were tested for in vitro cytostatic activity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a] pyrene) carcinogenesis and against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells. The silver(I) complexes 1-4 show strong activity. (C) 2007 Elsevier B. V. All rights reserved.
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bioinorganic chemistry, silver(i) complexes, tri(p-tolyl) phosphine, crystal structures, cytostatic activity, crystal-structure, 2-mercaptonicotinic acid, antimicrobial activities, heterocyclic thioamides, tertiary phosphines, antiviral activity, donor ligands, solid-state, in-vitro, gold(i)
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<Go to ISI>://000262978000042
http://ac.els-cdn.com/S0020169307004562/1-s2.0-S0020169307004562-main.pdf?_tid=fe8c1eec86fdae20cbb235eadfb95346&acdnat=1333030344_d838a4ed11fb058e29c5db952418568d
http://ac.els-cdn.com/S0020169307004562/1-s2.0-S0020169307004562-main.pdf?_tid=fe8c1eec86fdae20cbb235eadfb95346&acdnat=1333030344_d838a4ed11fb058e29c5db952418568d
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας