Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological study

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dc.contributor.authorZartilas, S.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorKyros, L.en
dc.contributor.authorKubicki, M.en
dc.contributor.authorBaril, M.en
dc.contributor.authorButler, I. S.en
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorBalzarini, J.en
dc.date.accessioned2015-11-24T16:50:04Z
dc.date.available2015-11-24T16:50:04Z
dc.identifier.issn0020-1693-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9564
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectsilver(i) complexesen
dc.subjecttri(p-tolyl) phosphineen
dc.subjectcrystal structuresen
dc.subjectcytostatic activityen
dc.subjectcrystal-structureen
dc.subject2-mercaptonicotinic aciden
dc.subjectantimicrobial activitiesen
dc.subjectheterocyclic thioamidesen
dc.subjecttertiary phosphinesen
dc.subjectantiviral activityen
dc.subjectdonor ligandsen
dc.subjectsolid-stateen
dc.subjectin-vitroen
dc.subjectgold(i)en
dc.titleTetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological studyen
heal.abstractSilver(I) halides react with tri(p-tolyl) phosphine (tptp, C(21)H(21)P) in MeOH/MeCN solutions in 1: 1 or 1: 3 molar ratios to give complexes of formulae {[AgCl(tptp)](4)} (1) or [AgX(tptp)(3)] (X = Cl (2), Br (3), I (4)), respectively. The complexes were characterized by elemental analyses, and FT-IR far-IR, FT-Raman, TG and (1)H, (13)C, (31)P NMR spectroscopic techniques. Crystal structures of complexes 2-4 were determined by X-ray diffraction at room temperature (rt). The crystal structure of 1 and 4 was also determined at 100(1) and 140(2) K (lt), respectively. In complex 1 four mu 3-Cl ions are bonded with four Ag(I) ions forming a cubane while the coordination sphere of silver(I) ions is completed by one P atom from a terminal tri(p-tolyl) phosphine ligand. In complexes 2-3 one terminal halogen and three P atoms from phosphine ligands form a tetrahedral arrangement around the metal ion. Complexes 1-4 were tested for in vitro cytostatic activity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a] pyrene) carcinogenesis and against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells. The silver(I) complexes 1-4 show strong activity. (C) 2007 Elsevier B. V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.ica.2007.07.034-
heal.identifier.secondary<Go to ISI>://000262978000042-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0020169307004562/1-s2.0-S0020169307004562-main.pdf?_tid=fe8c1eec86fdae20cbb235eadfb95346&acdnat=1333030344_d838a4ed11fb058e29c5db952418568d-
heal.journalNameInorganica Chimica Actaen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2009-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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