Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
Φόρτωση...
Ημερομηνία
Συγγραφείς
Apostolova, G.
Dorn, R.
Ka, S.
Hallbook, F.
Lundeberg, J.
Liser, K.
Hakim, V.
Brodski, C.
Michaelidis, T. M.
Dechant, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Molecular and Cellular Neuroscience
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
During late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were obtained from chick paravertebral sympathetic ganglia, treated with neurotrophin 3, glial cell line-derived neurotrophic factor or ciliary neurotrophic factor, all of which stimulate cholinergic differentiation. Results were compared with the effect of nerve growth factor, which functions as a pro-noradrenergic stimulus. The gene set common to all three comparisons defined the noradrenergic and cholinergic synexpression groups. Several functional categories, such as signal transduction, G-protein-coupled signaling, cation transport, neurogenesis and synaptic transmission, were enriched in these groups. Experiments based on the prediction that some of the identified genes play a role in the neurotransmitter switch identified bone morphogenetic protein signaling as an inhibitor of cholinergic differentiation. (c) 2007 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
acetylcholine, noradrenalin, sympathetic, neurotrophic, microarray, nerve growth-factor, cholinergic differentiation, neural crest, in-vivo, ganglia, system, induction, cytokines, pathways, signals
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000248057600001
http://ac.els-cdn.com/S1044743107000851/1-s2.0-S1044743107000851-main.pdf?_tid=1968a890d4e8d78d5867af7dcb70c114&acdnat=1336984347_ae2e29f286beeab224d5496f31f6bf7a
http://ac.els-cdn.com/S1044743107000851/1-s2.0-S1044743107000851-main.pdf?_tid=1968a890d4e8d78d5867af7dcb70c114&acdnat=1336984347_ae2e29f286beeab224d5496f31f6bf7a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών