Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons

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dc.contributor.authorApostolova, G.en
dc.contributor.authorDorn, R.en
dc.contributor.authorKa, S.en
dc.contributor.authorHallbook, F.en
dc.contributor.authorLundeberg, J.en
dc.contributor.authorLiser, K.en
dc.contributor.authorHakim, V.en
dc.contributor.authorBrodski, C.en
dc.contributor.authorMichaelidis, T. M.en
dc.contributor.authorDechant, G.en
dc.date.accessioned2015-11-24T16:33:47Z
dc.date.available2015-11-24T16:33:47Z
dc.identifier.issn1044-7431-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7712
dc.rightsDefault Licence-
dc.subjectacetylcholineen
dc.subjectnoradrenalinen
dc.subjectsympatheticen
dc.subjectneurotrophicen
dc.subjectmicroarrayen
dc.subjectnerve growth-factoren
dc.subjectcholinergic differentiationen
dc.subjectneural cresten
dc.subjectin-vivoen
dc.subjectgangliaen
dc.subjectsystemen
dc.subjectinductionen
dc.subjectcytokinesen
dc.subjectpathwaysen
dc.subjectsignalsen
dc.titleNeurotransmitter phenotype-specific expression changes in developing sympathetic neuronsen
heal.abstractDuring late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were obtained from chick paravertebral sympathetic ganglia, treated with neurotrophin 3, glial cell line-derived neurotrophic factor or ciliary neurotrophic factor, all of which stimulate cholinergic differentiation. Results were compared with the effect of nerve growth factor, which functions as a pro-noradrenergic stimulus. The gene set common to all three comparisons defined the noradrenergic and cholinergic synexpression groups. Several functional categories, such as signal transduction, G-protein-coupled signaling, cation transport, neurogenesis and synaptic transmission, were enriched in these groups. Experiments based on the prediction that some of the identified genes play a role in the neurotransmitter switch identified bone morphogenetic protein signaling as an inhibitor of cholinergic differentiation. (c) 2007 Elsevier Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.mcn.2007.03.014-
heal.identifier.secondary<Go to ISI>://000248057600001-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1044743107000851/1-s2.0-S1044743107000851-main.pdf?_tid=1968a890d4e8d78d5867af7dcb70c114&acdnat=1336984347_ae2e29f286beeab224d5496f31f6bf7a-
heal.journalNameMolecular and Cellular Neuroscienceen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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