Enzymatic transformation of flavonoids and terpenoids: Structural and functional diversity of the novel derivatives

dc.contributor.authorXanthakis, E.en
dc.contributor.authorTheodosiou, E.en
dc.contributor.authorMagkouta, S.en
dc.contributor.authorStamatis, H.en
dc.contributor.authorLoutrari, H.en
dc.contributor.authorRoussos, C.en
dc.contributor.authorKolisis, F.en
dc.date.accessioned2015-11-24T16:34:31Z
dc.date.available2015-11-24T16:34:31Z
dc.identifier.issn0033-4545-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7813
dc.rightsDefault Licence-
dc.subjectanti-tumor activityen
dc.subjectbiocatalysisen
dc.subjectflavonoidsen
dc.subjectphytochemicalsen
dc.subjectterpenoidsen
dc.subjectcandida-antarctica lipaseen
dc.subjectpolyhydroxylated natural compoundsen
dc.subjectregioselective acylationen
dc.subjectionic liquidsen
dc.subjectperillyl alcoholen
dc.subjectphenolic-acidsen
dc.subjectfatty-acidsen
dc.subjectcatalyzed esterificationen
dc.subjectcen
dc.titleEnzymatic transformation of flavonoids and terpenoids: Structural and functional diversity of the novel derivativesen
heal.abstractFlavonoids and terpenoids are promising candidates for use as functional foods and novel therapeutics due to their prominent biological activities. However, the use of several bioactive plant compounds is limited by low stability and solubility problems. This review underlines the feasibility of enzymatic synthesis of novel bioactive analogs of selected flavonoids (silybin, rutin) and terpenoids (perillyl alcohol, POH) in nonconventional reaction systems. The effect of various parameters on the enzymatic acylation and/or glucosylation of these phytochemicals was studied. Also, the role of the structure of the novel Molecules in relation to their biological function was investigated in various cancer cell lines.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1351/Pac-Con-09-01-19-
heal.identifier.secondary<Go to ISI>://000274709300002-
heal.identifier.secondaryhttp://www.docstoc.com/docs/65822968/Enzymatic-transformation-of-flavonoids-and-terpenoids-structural-and-functional-diversity-of-the-novel-derivatives(Report)-
heal.journalNamePure and Applied Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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