Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours
Φόρτωση...
Ημερομηνία
Συγγραφείς
Batistatou, A.
Kyzas, P. A.
Goussia, A.
Arkoumani, E.
Voulgaris, S.
Polyzoidis, K.
Agnantis, N. J.
Stefanou, D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Neurooncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Estrogen receptor beta (ERbeta) is an important mediator of estrogen function in a variety of tissues. Its expression declines in breast, ovarian, prostatic and colon carcinomas as well as in astrocytic tumours. BAG-1 is a multifunctional protein with an important role in neoplasia and is possibly regulated by estrogen receptors. One of the direct targets of BAG-1 is HSP70. The purpose of this study was to analyse the expression pattern of these proteins in two distinct types of glial neoplasms, to investigate their possible correlation and probe their impact on prognosis. ERbeta, BAG-1 and HSP70 protein expression was monitored immunohistochemically in 66 cases of astrocytomas and 20 oligodendrogliomas. In astrocytic tumours low ERbeta expression correlated significantly with high grade (P < 0.001), higher expression of cytoplasmic BAG-1 (P < 0.001) and worse survival (log rank P = 0.02). Multivariate analysis revealed that ERbeta expression had a prognostic value for overall survival in these patients (Cox P = 0.03), which was not dependent on grade. There was also statistically significant association of BAG-1 nuclear expression with HSP70 cytoplasmic expression. Our results strengthen the hypothesis that ERbeta, BAG-1 and HSP70 play an important role in the pathogenesis and progression of glial neoplasms. Moreover, ERbeta expression in astrocytic tumors might be an important prognostic factor for survival.
Περιγραφή
Λέξεις-κλειδιά
Aged, Astrocytoma/*metabolism/pathology, Brain Neoplasms/*metabolism/pathology, DNA-Binding Proteins/*metabolism, Estrogen Receptor beta/*metabolism, Female, Gene Expression Regulation, Neoplastic, HSP70 Heat-Shock Proteins/metabolism, Humans, Immunohistochemistry, Male, Middle Aged, Oligodendroglioma/*metabolism/pathology, Prognosis, Survival Analysis, Transcription Factors/*metabolism, Tumor Markers, Biological/metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16292491
http://www.springerlink.com/content/fr4n211160427417/fulltext.pdf
http://www.springerlink.com/content/fr4n211160427417/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής