Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours

Απλή σελίδα τεκμηρίου
dc.contributor.authorBatistatou, A.en
dc.contributor.authorKyzas, P. A.en
dc.contributor.authorGoussia, A.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorPolyzoidis, K.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorStefanou, D.en
dc.date.accessioned2015-11-24T19:18:05Z
dc.date.available2015-11-24T19:18:05Z
dc.identifier.issn0167-594X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21842
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAstrocytoma/*metabolism/pathologyen
dc.subjectBrain Neoplasms/*metabolism/pathologyen
dc.subjectDNA-Binding Proteins/*metabolismen
dc.subjectEstrogen Receptor beta/*metabolismen
dc.subjectFemaleen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectHSP70 Heat-Shock Proteins/metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOligodendroglioma/*metabolism/pathologyen
dc.subjectPrognosisen
dc.subjectSurvival Analysisen
dc.subjectTranscription Factors/*metabolismen
dc.subjectTumor Markers, Biological/metabolismen
dc.titleEstrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumoursen
heal.abstractEstrogen receptor beta (ERbeta) is an important mediator of estrogen function in a variety of tissues. Its expression declines in breast, ovarian, prostatic and colon carcinomas as well as in astrocytic tumours. BAG-1 is a multifunctional protein with an important role in neoplasia and is possibly regulated by estrogen receptors. One of the direct targets of BAG-1 is HSP70. The purpose of this study was to analyse the expression pattern of these proteins in two distinct types of glial neoplasms, to investigate their possible correlation and probe their impact on prognosis. ERbeta, BAG-1 and HSP70 protein expression was monitored immunohistochemically in 66 cases of astrocytomas and 20 oligodendrogliomas. In astrocytic tumours low ERbeta expression correlated significantly with high grade (P < 0.001), higher expression of cytoplasmic BAG-1 (P < 0.001) and worse survival (log rank P = 0.02). Multivariate analysis revealed that ERbeta expression had a prognostic value for overall survival in these patients (Cox P = 0.03), which was not dependent on grade. There was also statistically significant association of BAG-1 nuclear expression with HSP70 cytoplasmic expression. Our results strengthen the hypothesis that ERbeta, BAG-1 and HSP70 play an important role in the pathogenesis and progression of glial neoplasms. Moreover, ERbeta expression in astrocytic tumors might be an important prognostic factor for survival.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s11060-005-9005-0-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16292491-
heal.identifier.secondaryhttp://www.springerlink.com/content/fr4n211160427417/fulltext.pdf-
heal.journalNameJ Neurooncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ