Novel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluation
Φόρτωση...
Ημερομηνία
Συγγραφείς
Papadopoulos, M.
Nock, B.
Maina, T.
Pirmettis, I.
Raptopoulou, C.
Tasiopoulos, A.
Troganis, A.
Kabanos, T.
Terzis, A.
Chiotellis, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Springer Verlag (Germany)
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Biological Inorganic Chemistry
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Novel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L3- With the suitable MO3+ precursor, the following neutral MOL complexes could be easily produced following similar synthetic routes: M=Re (1), M=(TC)-T-99g (2) and M=Tc-99m (3). Complexes 1 and 2, prepared in macroscopic amounts, were chemically characterized and their structure determined by single-crystal X-ray analysis. They are isostructural metal chelates, adopting a distorted square pyramidal geometry around the metal. The N3O donor atom set of the tetradentate ligand defines the basal plane and the oxygen atom of the M=O core occupies the apex of the pyramid. Complex 3 forms quantitatively at tracer level by mixing the H3L ligand with (NaTcO4)-Tc-99m generator eluate in aqueous alkaline media and using tin chloride as reductant in the presence of citrate. Its structure was established by chromatographic comparison with prototypic complexes 1 and 2 using high-performance liquid chromatographic techniques. When challenged with excess glutathione in vitro, complex 3 is rapidly converted to hydrophilic unidentified metal species. Tissue distribution data after administration of complex 3 in vivo revealed a significant uptake and retention of this compound in brain tissue.
Περιγραφή
Λέξεις-κλειδιά
rhenium, technetium, technetium-99m agent, brain perfusion, retention mechanism, technetium-99m l,l-ecd, rhenium(v), perfusion, ligands, ecd
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000167176900007
http://www.springerlink.com/content/74nv1c7q1mpun9p9/fulltext.pdf
http://www.springerlink.com/content/74nv1c7q1mpun9p9/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας