Novel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluation

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dc.contributor.authorPapadopoulos, M.en
dc.contributor.authorNock, B.en
dc.contributor.authorMaina, T.en
dc.contributor.authorPirmettis, I.en
dc.contributor.authorRaptopoulou, C.en
dc.contributor.authorTasiopoulos, A.en
dc.contributor.authorTroganis, A.en
dc.contributor.authorKabanos, T.en
dc.contributor.authorTerzis, A.en
dc.contributor.authorChiotellis, E.en
dc.date.accessioned2015-11-24T16:42:53Z
dc.date.available2015-11-24T16:42:53Z
dc.identifier.issn0949-8257-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8614
dc.rightsDefault Licence-
dc.subjectrheniumen
dc.subjecttechnetiumen
dc.subjecttechnetium-99m agenten
dc.subjectbrain perfusionen
dc.subjectretention mechanismen
dc.subjecttechnetium-99m l,l-ecden
dc.subjectrhenium(v)en
dc.subjectperfusionen
dc.subjectligandsen
dc.subjectecden
dc.titleNovel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluationen
heal.abstractNovel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L3- With the suitable MO3+ precursor, the following neutral MOL complexes could be easily produced following similar synthetic routes: M=Re (1), M=(TC)-T-99g (2) and M=Tc-99m (3). Complexes 1 and 2, prepared in macroscopic amounts, were chemically characterized and their structure determined by single-crystal X-ray analysis. They are isostructural metal chelates, adopting a distorted square pyramidal geometry around the metal. The N3O donor atom set of the tetradentate ligand defines the basal plane and the oxygen atom of the M=O core occupies the apex of the pyramid. Complex 3 forms quantitatively at tracer level by mixing the H3L ligand with (NaTcO4)-Tc-99m generator eluate in aqueous alkaline media and using tin chloride as reductant in the presence of citrate. Its structure was established by chromatographic comparison with prototypic complexes 1 and 2 using high-performance liquid chromatographic techniques. When challenged with excess glutathione in vitro, complex 3 is rapidly converted to hydrophilic unidentified metal species. Tissue distribution data after administration of complex 3 in vivo revealed a significant uptake and retention of this compound in brain tissue.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000167176900007-
heal.identifier.secondaryhttp://www.springerlink.com/content/74nv1c7q1mpun9p9/fulltext.pdf-
heal.journalNameJournal of Biological Inorganic Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.publisherSpringer Verlag (Germany)en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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