Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia
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Kostapanos, M. S.
Milionis, H. J.
Gazi, I.
Kostara, C.
Bairaktari, E. T.
Elisaf, M. S.
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peer-reviewed
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J Clin Pharmacol
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The renoprotective effect of statins has been recently disputed because of observations of proteinuria associated with rosuvastatin treatment, the newest drug of the class. Statin-induced proteinuria findings were mainly based on crudely quantitative dipstick assays. The authors quantitatively evaluated the effect of rosuvastatin at the recommended starting dose of 10 mg/d, on urine protein excretion in patients with primary dyslipidemia. Serum lipid and nonlipid parameters as well as urinary electrolyte, creatinine, and protein (total, albumin, immunoglobulin G, and alpha-1 microglobulin) levels were measured in 40 patients treated with rosuvastatin and 30 controls at baseline and after 12 weeks. The protein-to-creatinine ratios were used to assess urinary protein excretion. Rosuvastatin improved the lipid profile, produced no deterioration of kidney function, but induced a small but significant increase in the excretion of alpha-1 microglobulin (by 16%, P < .05) indicating that statin-related proteinuria involves low-molecular-weight proteins and is of proximal tubular origin.
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Keywords
Adult, Aged, Alpha-Globulins/*urine, Female, Fluorobenzenes/*pharmacology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology, Hyperlipoproteinemia Type II/*drug therapy, Male, Middle Aged, Pyrimidines/*pharmacology, Sulfonamides/*pharmacology
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http://www.ncbi.nlm.nih.gov/pubmed/17050799
http://jcp.sagepub.com/content/46/11/1337.full.pdf
http://jcp.sagepub.com/content/46/11/1337.full.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής