Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia

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dc.contributor.authorKostapanos, M. S.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorGazi, I.en
dc.contributor.authorKostara, C.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T18:53:04Z
dc.date.available2015-11-24T18:53:04Z
dc.identifier.issn0091-2700-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18490
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAlpha-Globulins/*urineen
dc.subjectFemaleen
dc.subjectFluorobenzenes/*pharmacologyen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacologyen
dc.subjectHyperlipoproteinemia Type II/*drug therapyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPyrimidines/*pharmacologyen
dc.subjectSulfonamides/*pharmacologyen
dc.titleRosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemiaen
heal.abstractThe renoprotective effect of statins has been recently disputed because of observations of proteinuria associated with rosuvastatin treatment, the newest drug of the class. Statin-induced proteinuria findings were mainly based on crudely quantitative dipstick assays. The authors quantitatively evaluated the effect of rosuvastatin at the recommended starting dose of 10 mg/d, on urine protein excretion in patients with primary dyslipidemia. Serum lipid and nonlipid parameters as well as urinary electrolyte, creatinine, and protein (total, albumin, immunoglobulin G, and alpha-1 microglobulin) levels were measured in 40 patients treated with rosuvastatin and 30 controls at baseline and after 12 weeks. The protein-to-creatinine ratios were used to assess urinary protein excretion. Rosuvastatin improved the lipid profile, produced no deterioration of kidney function, but induced a small but significant increase in the excretion of alpha-1 microglobulin (by 16%, P < .05) indicating that statin-related proteinuria involves low-molecular-weight proteins and is of proximal tubular origin.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1177/0091270006292629-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17050799-
heal.identifier.secondaryhttp://jcp.sagepub.com/content/46/11/1337.full.pdf-
heal.journalNameJ Clin Pharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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