Circulating endothelin-3 levels in patients with sickle cell disease during hydroxyurea treatment
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Date
Authors
Makis, A. C.
Hatzimichael, E. C.
Kolios, G.
Bourantas, K. L.
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peer-reviewed
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Haematologica
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Description
Abnormal adhesion of red blood cells to the endothelium and the production of cytokines and vasoactive substances, such as endothelin-1 contribute to the pathogenesis of microvascular occlusion in sickle cell disease (SCD), even during the steady state. Endothelin-3 (ET-3) is a vasoconstrictive agent, which has not yet been studied in SCD.
Description
Keywords
Adult, Anemia, Sickle Cell/*blood/*drug therapy, Antisickling Agents/*therapeutic use, Endothelin-3/*blood, Female, Humans, Hydroxyurea/*therapeutic use, Male, Middle Aged
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http://www.ncbi.nlm.nih.gov/pubmed/15020278
Language
en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής