Prognostic factors and outcomes for osteosarcoma: an international collaboration
Φόρτωση...
Ημερομηνία
Συγγραφείς
Pakos, E. E.
Nearchou, A. D.
Grimer, R. J.
Koumoullis, H. D.
Abudu, A.
Bramer, J. A.
Jeys, L. M.
Franchi, A.
Scoccianti, G.
Campanacci, D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Amputation/*mortality, *Bone Neoplasms/mortality/pathology/therapy, Confidence Intervals, Female, Humans, *International Cooperation, Limb Salvage/*mortality, Male, *Osteosarcoma/mortality/secondary/therapy, Prognosis, Young Adult
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19349163
http://ac.els-cdn.com/S0959804909001774/1-s2.0-S0959804909001774-main.pdf?_tid=e57a3efd6ac7e16bd7fa43d1a39544d1&acdnat=1333363675_086d0ca5a8cfae12e9a86c0371617009
http://ac.els-cdn.com/S0959804909001774/1-s2.0-S0959804909001774-main.pdf?_tid=e57a3efd6ac7e16bd7fa43d1a39544d1&acdnat=1333363675_086d0ca5a8cfae12e9a86c0371617009
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής