Prognostic factors and outcomes for osteosarcoma: an international collaboration

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dc.contributor.authorPakos, E. E.en
dc.contributor.authorNearchou, A. D.en
dc.contributor.authorGrimer, R. J.en
dc.contributor.authorKoumoullis, H. D.en
dc.contributor.authorAbudu, A.en
dc.contributor.authorBramer, J. A.en
dc.contributor.authorJeys, L. M.en
dc.contributor.authorFranchi, A.en
dc.contributor.authorScoccianti, G.en
dc.contributor.authorCampanacci, D.en
dc.contributor.authorCapanna, R.en
dc.contributor.authorAparicio, J.en
dc.contributor.authorTabone, M. D.en
dc.contributor.authorHolzer, G.en
dc.contributor.authorAbdolvahab, F.en
dc.contributor.authorFunovics, P.en
dc.contributor.authorDominkus, M.en
dc.contributor.authorIlhan, I.en
dc.contributor.authorBerrak, S. G.en
dc.contributor.authorPatino-Garcia, A.en
dc.contributor.authorSierrasesumaga, L.en
dc.contributor.authorSan-Julian, M.en
dc.contributor.authorGarraus, M.en
dc.contributor.authorPetrilli, A. S.en
dc.contributor.authorFilho, R. J.en
dc.contributor.authorMacedo, C. R.en
dc.contributor.authorAlves, M. T.en
dc.contributor.authorSeiwerth, S.en
dc.contributor.authorNagarajan, R.en
dc.contributor.authorCripe, T. P.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T18:56:22Z
dc.date.available2015-11-24T18:56:22Z
dc.identifier.issn1879-0852-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19027
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAmputation/*mortalityen
dc.subject*Bone Neoplasms/mortality/pathology/therapyen
dc.subjectConfidence Intervalsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subject*International Cooperationen
dc.subjectLimb Salvage/*mortalityen
dc.subjectMaleen
dc.subject*Osteosarcoma/mortality/secondary/therapyen
dc.subjectPrognosisen
dc.subjectYoung Adulten
dc.titlePrognostic factors and outcomes for osteosarcoma: an international collaborationen
heal.abstractWe aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejca.2009.03.005-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19349163-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0959804909001774/1-s2.0-S0959804909001774-main.pdf?_tid=e57a3efd6ac7e16bd7fa43d1a39544d1&acdnat=1333363675_086d0ca5a8cfae12e9a86c0371617009-
heal.journalNameEur J Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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