Synthesis of a proline-rich [60]fullerene peptide with potential biological activity

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dc.contributor.authorSofou, P.en
dc.contributor.authorElemes, Y.en
dc.contributor.authorPanou-Pomonis, E.en
dc.contributor.authorStavrakoudis, A.en
dc.contributor.authorTsikaris, V.en
dc.contributor.authorSakarellos, C.en
dc.contributor.authorSakarellos-Daitsiotis, M.en
dc.contributor.authorMaggini, M.en
dc.contributor.authorFormaggio, F.en
dc.contributor.authorToniolo, C.en
dc.date.accessioned2015-11-24T16:49:14Z
dc.date.available2015-11-24T16:49:14Z
dc.identifier.issn0040-4020-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9452
dc.rightsDefault Licence-
dc.subjectfullerenesen
dc.subjectazomethine ylidesen
dc.subject1,3-dipolar cycloadditionsen
dc.subjectfullerene peptidesen
dc.subjectsequential oligopeptide carriersen
dc.subjectfullerene derivativesen
dc.subjecthiv-1 proteaseen
dc.subjectrepetitive epitopeen
dc.subjectsm autoantigenen
dc.subjectamino-aciden
dc.subjectc-60en
dc.subjectchemistryen
dc.subjectinhibitorsen
dc.subjectfulleroprolineen
dc.titleSynthesis of a proline-rich [60]fullerene peptide with potential biological activityen
heal.abstractA proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product 8 as a TFA salt, with oxidized methionine. Product 8 was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment). (C) 2004 Elsevier Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.tet.2004.01.064-
heal.identifier.secondary<Go to ISI>://000220257900011-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0040402004001425/1-s2.0-S0040402004001425-main.pdf?_tid=7431152d2201be2b98ace118131474bf&acdnat=1333038804_8952a6ca64cb771d4032b9319ee5bdfd-
heal.journalNameTetrahedronen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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