Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature
Φόρτωση...
Ημερομηνία
Συγγραφείς
Pentheroudakis, G.
White, J.
Davis, J.
Brown, I.
Vasey, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Gynecol Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Nongestational choriocarcinomas are aggressive tumours occurring either as a global event or as a focal change in solid tumours. The latter is responsible for coexistence of trophoblastic histology with other malignancies. CASE: A 65-year old female with stage IV primary peritoneal carcinoma, ovarian type, underwent surgical cytoreduction followed by two courses of paclitaxel/carboplatin chemotherapy. A choriocarcinomatous component was later identified in the resection specimens, as chemotherapy resulted in a differential response of the two malignant variants. Commencement of EMA/CO chemotherapy (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) resulted in symptom palliation and tumour regression, further consolidated with platinum-based EP/EMA (etoposide, cisplatin, methotrexate, actinomycin D). Two months later, relentless choriocarcinomatous disease progression followed, leading to the patient's death while the peritoneal adenocarcinomatous variant remained biochemically quiescent. CONCLUSION: Choriocarcinomas may coexist with typical ovarian-type peritoneal cancer, creating diagnostic and therapeutic dilemmas. Aggressive weekly chorio-type chemotherapy appears to be warranted despite the low likelihood of cure, as it provides significant symptom palliation.
Περιγραφή
Λέξεις-κλειδιά
Adenocarcinoma/*drug therapy/pathology/surgery, Aged, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Choriocarcinoma, Non-gestational/*drug therapy/pathology/surgery, Combined Modality Therapy, Female, Humans, Ovarian Neoplasms/*drug therapy/pathology/surgery, Peritoneal Neoplasms/*drug therapy/pathology/surgery
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/14766269
http://ac.els-cdn.com/S0090825803007649/1-s2.0-S0090825803007649-main.pdf?_tid=0a3ce2605ed1bf5f0e8a08a8f0dd8697&acdnat=1333955113_9bd090627085562cf254017501956e8f
http://ac.els-cdn.com/S0090825803007649/1-s2.0-S0090825803007649-main.pdf?_tid=0a3ce2605ed1bf5f0e8a08a8f0dd8697&acdnat=1333955113_9bd090627085562cf254017501956e8f
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής