Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature
| dc.contributor.author | Pentheroudakis, G. | en |
| dc.contributor.author | White, J. | en |
| dc.contributor.author | Davis, J. | en |
| dc.contributor.author | Brown, I. | en |
| dc.contributor.author | Vasey, P. | en |
| dc.date.accessioned | 2015-11-24T19:27:54Z | |
| dc.date.available | 2015-11-24T19:27:54Z | |
| dc.identifier.issn | 0090-8258 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22851 | |
| dc.rights | Default Licence | - |
| dc.subject | Adenocarcinoma/*drug therapy/pathology/surgery | en |
| dc.subject | Aged | en |
| dc.subject | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use | en |
| dc.subject | Choriocarcinoma, Non-gestational/*drug therapy/pathology/surgery | en |
| dc.subject | Combined Modality Therapy | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Ovarian Neoplasms/*drug therapy/pathology/surgery | en |
| dc.subject | Peritoneal Neoplasms/*drug therapy/pathology/surgery | en |
| dc.title | Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature | en |
| heal.abstract | BACKGROUND: Nongestational choriocarcinomas are aggressive tumours occurring either as a global event or as a focal change in solid tumours. The latter is responsible for coexistence of trophoblastic histology with other malignancies. CASE: A 65-year old female with stage IV primary peritoneal carcinoma, ovarian type, underwent surgical cytoreduction followed by two courses of paclitaxel/carboplatin chemotherapy. A choriocarcinomatous component was later identified in the resection specimens, as chemotherapy resulted in a differential response of the two malignant variants. Commencement of EMA/CO chemotherapy (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) resulted in symptom palliation and tumour regression, further consolidated with platinum-based EP/EMA (etoposide, cisplatin, methotrexate, actinomycin D). Two months later, relentless choriocarcinomatous disease progression followed, leading to the patient's death while the peritoneal adenocarcinomatous variant remained biochemically quiescent. CONCLUSION: Choriocarcinomas may coexist with typical ovarian-type peritoneal cancer, creating diagnostic and therapeutic dilemmas. Aggressive weekly chorio-type chemotherapy appears to be warranted despite the low likelihood of cure, as it provides significant symptom palliation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.ygyno.2003.10.049 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14766269 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0090825803007649/1-s2.0-S0090825803007649-main.pdf?_tid=0a3ce2605ed1bf5f0e8a08a8f0dd8697&acdnat=1333955113_9bd090627085562cf254017501956e8f | - |
| heal.journalName | Gynecol Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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