Cyclosporin-associated nephropathy in patients with autoimmune diseases
Φόρτωση...
Ημερομηνία
Συγγραφείς
Mihatsch, M. J.
Bach, J. F.
Coovadia, H. M.
Forre, O.
Moutsopoulos, H. M.
Drosos, A. A.
Siamopoulos, K. C.
Noel, L. H.
Ramsaroop, R.
Hallgren, R.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Klin Wochenschr
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (less than 7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (greater than 7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses.
Περιγραφή
Λέξεις-κλειδιά
Adult, Autoimmune Diseases/*drug therapy, Cyclosporins/*adverse effects/therapeutic use, Dose-Response Relationship, Drug, Female, Humans, Kidney Diseases/*chemically induced, Kidney Function Tests, Kidney Glomerulus/drug effects, Kidney Tubules/drug effects, Male, Middle Aged, Nephritis, Interstitial/chemically induced, Renal Artery/drug effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/3347004
http://www.springerlink.com/content/v4576w79744l44g0/fulltext.pdf
http://www.springerlink.com/content/v4576w79744l44g0/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής