Cyclosporin-associated nephropathy in patients with autoimmune diseases

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dc.contributor.authorMihatsch, M. J.en
dc.contributor.authorBach, J. F.en
dc.contributor.authorCoovadia, H. M.en
dc.contributor.authorForre, O.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorSiamopoulos, K. C.en
dc.contributor.authorNoel, L. H.en
dc.contributor.authorRamsaroop, R.en
dc.contributor.authorHallgren, R.en
dc.contributor.authoret al.,en
dc.date.accessioned2015-11-24T19:25:44Z
dc.date.available2015-11-24T19:25:44Z
dc.identifier.issn0023-2173-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22650
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAutoimmune Diseases/*drug therapyen
dc.subjectCyclosporins/*adverse effects/therapeutic useen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKidney Diseases/*chemically induceden
dc.subjectKidney Function Testsen
dc.subjectKidney Glomerulus/drug effectsen
dc.subjectKidney Tubules/drug effectsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNephritis, Interstitial/chemically induceden
dc.subjectRenal Artery/drug effectsen
dc.titleCyclosporin-associated nephropathy in patients with autoimmune diseasesen
heal.abstractRenal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (less than 7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (greater than 7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3347004-
heal.identifier.secondaryhttp://www.springerlink.com/content/v4576w79744l44g0/fulltext.pdf-
heal.journalNameKlin Wochenschren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1988-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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