External beam irradiation in angioplasted arteries of hypercholesterolemic rabbits. The dose and time effect
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kalef-Ezra, J.
Michalis, L. K.
Malamou-Mitsi, V.
Tsekeris, P.
Katsouras, C.
Boziari, A.
Toumpoulis, I.
Bozios, G.
Charchanti, A.
Sideris, D. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cardiovasc Radiat Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: To study the dose and time effect of external beam irradiation on the morphometry of both angioplasted and nonangioplasted arteries in a hypercholesterolemic rabbit model. METHODS AND MATERIALS: Eight groups of rabbit femoral arteries were studied: arteries (a) with no intervention, (b) irradiated with a 12-Gy 6 MV X-ray dose, (c) with a 18-Gy, (d) treated with balloon angioplasty, (e) dosed with 12-Gy half an hour post-angioplasty, (f) dosed with 18-Gy half an hour post-angioplasty, (g) dosed with 12-Gy 48 h post angioplasty, (g) dosed with 18-Gy 48 h post angioplasty. RESULTS: External irradiation at either 12 or 18 Gy was not found to change vessel morphometry in noninjured arteries. The 12-Gy dose given soon after angioplasty further increased percentage stenosis (63% on the average), despite the preservation of the lumen cross-sectional area. Positive remodeling was not observed in arteries given 18-Gy half an hour post angioplasty to counterbalance the increased neointimal formation. Therefore, this treatment resulted in a drastic reduction in lumen area and in enhancement of percentage stenosis (84% on the average). On the contrary, the delayed irradiation of the angioplasted arteries at either 12 or 18 Gy was not found to influence any of the studied morphometric parameters 5 weeks after angioplasty. CONCLUSIONS: Uniform external beam irradiation up to 18 Gy was well tolerated by intact femoral arteries. Prompt 12- or 18-Gy irradiations accentuated percentage stenosis. However the lumen cross-sectional area was preserved only at the lower dose point. Delayed irradiation at any dose did not influence the restenosis process.
Περιγραφή
Λέξεις-κλειδιά
*Angioplasty, Balloon, Animals, Arterial Occlusive Diseases/etiology, Disease Models, Animal, Dose-Response Relationship, Radiation, Femoral Artery/*radiation effects/*surgery, Hypercholesterolemia/complications/*therapy, Male, Postoperative Complications/etiology, Rabbits, Radiotherapy Dosage, Time Factors, Treatment Outcome, Tunica Intima/radiation effects/surgery, Tunica Media/radiation effects/surgery, *X-Ray Therapy
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12479912
http://ac.els-cdn.com/S1522186502001439/1-s2.0-S1522186502001439-main.pdf?_tid=2b7c9935c7e7078341b3fc66d45956c3&acdnat=1337844416_1bc327c02bda6c780a459948ab02e940
http://ac.els-cdn.com/S1522186502001439/1-s2.0-S1522186502001439-main.pdf?_tid=2b7c9935c7e7078341b3fc66d45956c3&acdnat=1337844416_1bc327c02bda6c780a459948ab02e940
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής