External beam irradiation in angioplasted arteries of hypercholesterolemic rabbits. The dose and time effect

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dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorTsekeris, P.en
dc.contributor.authorKatsouras, C.en
dc.contributor.authorBoziari, A.en
dc.contributor.authorToumpoulis, I.en
dc.contributor.authorBozios, G.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorSideris, D. A.en
dc.date.accessioned2015-11-24T19:16:24Z
dc.date.available2015-11-24T19:16:24Z
dc.identifier.issn1522-1865-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21658
dc.rightsDefault Licence-
dc.subject*Angioplasty, Balloonen
dc.subjectAnimalsen
dc.subjectArterial Occlusive Diseases/etiologyen
dc.subjectDisease Models, Animalen
dc.subjectDose-Response Relationship, Radiationen
dc.subjectFemoral Artery/*radiation effects/*surgeryen
dc.subjectHypercholesterolemia/complications/*therapyen
dc.subjectMaleen
dc.subjectPostoperative Complications/etiologyen
dc.subjectRabbitsen
dc.subjectRadiotherapy Dosageen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.subjectTunica Intima/radiation effects/surgeryen
dc.subjectTunica Media/radiation effects/surgeryen
dc.subject*X-Ray Therapyen
dc.titleExternal beam irradiation in angioplasted arteries of hypercholesterolemic rabbits. The dose and time effecten
heal.abstractPURPOSE: To study the dose and time effect of external beam irradiation on the morphometry of both angioplasted and nonangioplasted arteries in a hypercholesterolemic rabbit model. METHODS AND MATERIALS: Eight groups of rabbit femoral arteries were studied: arteries (a) with no intervention, (b) irradiated with a 12-Gy 6 MV X-ray dose, (c) with a 18-Gy, (d) treated with balloon angioplasty, (e) dosed with 12-Gy half an hour post-angioplasty, (f) dosed with 18-Gy half an hour post-angioplasty, (g) dosed with 12-Gy 48 h post angioplasty, (g) dosed with 18-Gy 48 h post angioplasty. RESULTS: External irradiation at either 12 or 18 Gy was not found to change vessel morphometry in noninjured arteries. The 12-Gy dose given soon after angioplasty further increased percentage stenosis (63% on the average), despite the preservation of the lumen cross-sectional area. Positive remodeling was not observed in arteries given 18-Gy half an hour post angioplasty to counterbalance the increased neointimal formation. Therefore, this treatment resulted in a drastic reduction in lumen area and in enhancement of percentage stenosis (84% on the average). On the contrary, the delayed irradiation of the angioplasted arteries at either 12 or 18 Gy was not found to influence any of the studied morphometric parameters 5 weeks after angioplasty. CONCLUSIONS: Uniform external beam irradiation up to 18 Gy was well tolerated by intact femoral arteries. Prompt 12- or 18-Gy irradiations accentuated percentage stenosis. However the lumen cross-sectional area was preserved only at the lower dose point. Delayed irradiation at any dose did not influence the restenosis process.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12479912-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1522186502001439/1-s2.0-S1522186502001439-main.pdf?_tid=2b7c9935c7e7078341b3fc66d45956c3&acdnat=1337844416_1bc327c02bda6c780a459948ab02e940-
heal.journalNameCardiovasc Radiat Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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