Is vitamin C superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting?
Φόρτωση...
Ημερομηνία
Συγγραφείς
Drossos, G. E.
Toumpoulis, I. K.
Katritsis, D. G.
Ioannidis, J. P.
Kontogiorgi, P.
Svarna, E.
Anagnostopoulos, C. E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Thorac Cardiovasc Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVES: We aimed to measure the vasodilating effects of vitamin C on the radial arteries of healthy subjects and to assess whether vitamin C is superior in this regard to diltiazem, a commonly used vasodilator in coronary artery bypass using radial conduits. METHODS: In a case-control study (study 1) oral single-dose vitamin C (2 g) was given to 15 healthy nonsmokers and 15 matched otherwise healthy smokers. In a randomized double-blind study (study 2) oral single-dose vitamin C (2 g, n = 15) and diltiazem (180 mg, n = 15) were compared in preoperative patients with coronary artery disease. We examined the dilation of the radial artery with high-resolution ultrasonography and measurement of the lumen surface and color Doppler images of the nondominant radial artery just before and 2 hours after drug administration. RESULTS: In study 1 both smokers and nonsmokers showed a significant increase in the lumen surface at 2 hours compared with at baseline (P <.001 and P =.013, respectively). The increase was larger in smokers (median, 37.5% vs 14.3%; P =.004). In study 2 both groups showed statistically significant increases in the lumen surface at 2 hours compared with at baseline (P <.001 and P =.008 for vitamin C and diltiazem, respectively). Vitamin C achieved a larger increase than diltiazem (median, 33.3% vs 18.2%; P =.016). In multivariate modeling the increase in lumen surface was independently predicted by use of vitamin C over diltiazem (+21.2%, P =.007), diabetes mellitus (+14.5%, P =.085), increased cholesterol (+26.2%, P =.001), and smoking history (+20.8%, P =.017). CONCLUSIONS: Vitamin C is a potent acute vasodilator in both smokers and nonsmokers and is superior to diltiazem in preoperative coronary patients who need protection from vasospasm of the radial conduit.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Ascorbic Acid/pharmacology/*therapeutic use, Case-Control Studies, Coronary Artery Bypass/*methods, Coronary Disease/*drug therapy/etiology/physiopathology/surgery/ultrasonography, Diabetes Complications, Diltiazem/pharmacology/*therapeutic use, Double-Blind Method, Female, Humans, Hypercholesterolemia/complications, Male, Middle Aged, Multivariate Analysis, Pilot Projects, Predictive Value of Tests, Radial Artery/*drug effects/physiopathology/*transplantation/ultrasonography, Smoking/adverse effects/*drug therapy/physiopathology, Ultrasonography, Doppler, Color, Vasodilation/*drug effects, Vasodilator Agents/pharmacology/*therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12579102
http://ac.els-cdn.com/S0022522302732509/1-s2.0-S0022522302732509-main.pdf?_tid=a174db30884480662f80e7e4aca4d7a0&acdnat=1333364520_cc26c5666019de8cf37c7a41d41c736b
http://ac.els-cdn.com/S0022522302732509/1-s2.0-S0022522302732509-main.pdf?_tid=a174db30884480662f80e7e4aca4d7a0&acdnat=1333364520_cc26c5666019de8cf37c7a41d41c736b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής