Is vitamin C superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting?
| dc.contributor.author | Drossos, G. E. | en |
| dc.contributor.author | Toumpoulis, I. K. | en |
| dc.contributor.author | Katritsis, D. G. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Kontogiorgi, P. | en |
| dc.contributor.author | Svarna, E. | en |
| dc.contributor.author | Anagnostopoulos, C. E. | en |
| dc.date.accessioned | 2015-11-24T19:08:46Z | |
| dc.date.available | 2015-11-24T19:08:46Z | |
| dc.identifier.issn | 0022-5223 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20589 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Ascorbic Acid/pharmacology/*therapeutic use | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Coronary Artery Bypass/*methods | en |
| dc.subject | Coronary Disease/*drug therapy/etiology/physiopathology/surgery/ultrasonography | en |
| dc.subject | Diabetes Complications | en |
| dc.subject | Diltiazem/pharmacology/*therapeutic use | en |
| dc.subject | Double-Blind Method | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Hypercholesterolemia/complications | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Multivariate Analysis | en |
| dc.subject | Pilot Projects | en |
| dc.subject | Predictive Value of Tests | en |
| dc.subject | Radial Artery/*drug effects/physiopathology/*transplantation/ultrasonography | en |
| dc.subject | Smoking/adverse effects/*drug therapy/physiopathology | en |
| dc.subject | Ultrasonography, Doppler, Color | en |
| dc.subject | Vasodilation/*drug effects | en |
| dc.subject | Vasodilator Agents/pharmacology/*therapeutic use | en |
| dc.title | Is vitamin C superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting? | en |
| heal.abstract | OBJECTIVES: We aimed to measure the vasodilating effects of vitamin C on the radial arteries of healthy subjects and to assess whether vitamin C is superior in this regard to diltiazem, a commonly used vasodilator in coronary artery bypass using radial conduits. METHODS: In a case-control study (study 1) oral single-dose vitamin C (2 g) was given to 15 healthy nonsmokers and 15 matched otherwise healthy smokers. In a randomized double-blind study (study 2) oral single-dose vitamin C (2 g, n = 15) and diltiazem (180 mg, n = 15) were compared in preoperative patients with coronary artery disease. We examined the dilation of the radial artery with high-resolution ultrasonography and measurement of the lumen surface and color Doppler images of the nondominant radial artery just before and 2 hours after drug administration. RESULTS: In study 1 both smokers and nonsmokers showed a significant increase in the lumen surface at 2 hours compared with at baseline (P <.001 and P =.013, respectively). The increase was larger in smokers (median, 37.5% vs 14.3%; P =.004). In study 2 both groups showed statistically significant increases in the lumen surface at 2 hours compared with at baseline (P <.001 and P =.008 for vitamin C and diltiazem, respectively). Vitamin C achieved a larger increase than diltiazem (median, 33.3% vs 18.2%; P =.016). In multivariate modeling the increase in lumen surface was independently predicted by use of vitamin C over diltiazem (+21.2%, P =.007), diabetes mellitus (+14.5%, P =.085), increased cholesterol (+26.2%, P =.001), and smoking history (+20.8%, P =.017). CONCLUSIONS: Vitamin C is a potent acute vasodilator in both smokers and nonsmokers and is superior to diltiazem in preoperative coronary patients who need protection from vasospasm of the radial conduit. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1067/mtc.2003.3 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12579102 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0022522302732509/1-s2.0-S0022522302732509-main.pdf?_tid=a174db30884480662f80e7e4aca4d7a0&acdnat=1333364520_cc26c5666019de8cf37c7a41d41c736b | - |
| heal.journalName | J Thorac Cardiovasc Surg | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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