Sequential oligopetide carriers, SOCn, as scaffolds for the reconstitution of antigenic proteins: applications in solid phase immunoassays
| dc.contributor.author | Sakarellos-Daitsiotis, M. | en |
| dc.contributor.author | Alexopoulos, C. | en |
| dc.contributor.author | Sakarellos, C. | en |
| dc.date.accessioned | 2015-11-24T16:47:01Z | |
| dc.date.available | 2015-11-24T16:47:01Z | |
| dc.identifier.issn | 0731-7085 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9131 | |
| dc.rights | Default Licence | - |
| dc.subject | oligopeptide carriers | en |
| dc.subject | antigenic proteins | en |
| dc.subject | solid phase immunoassays | en |
| dc.subject | main immunogenic region | en |
| dc.subject | nicotinic acetylcholine-receptor | en |
| dc.subject | anti-sm antibodies | en |
| dc.subject | oligopeptide carriers | en |
| dc.subject | glycopeptide dendrimers | en |
| dc.subject | synthetic peptide | en |
| dc.subject | epitope | en |
| dc.subject | autoantibodies | en |
| dc.subject | specificity | en |
| dc.subject | design | en |
| dc.title | Sequential oligopetide carriers, SOCn, as scaffolds for the reconstitution of antigenic proteins: applications in solid phase immunoassays | en |
| heal.abstract | A new class of helicoid type sequential oligopeptide carriers (SOC), for anchoring antigenic epitopes, has been modeled from the repetitive Lys-Aib-Gly (SOCn-I) and Aib-Lys-Aib-Gly (SOCn-II) units aiming to the development of scaffolds with predetermined 3D structures. Conformational analysis showed that the SOCn carriers adopt 3(10)-helical structures, while the SOCn-conjugates retain their original active conformations and they interact neither to the carriers nor to each other. It is concluded that the helicoid structure of SOC,, helps the reconstitution and/or mimicking of the native forms of the epitopes so that potent antigens are generated for developing specific, sensitive and reproducible immunoassays. (C) 2003 Elsevier B.V. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1016/S0731-7085(03)00561-2 | - |
| heal.identifier.secondary | <Go to ISI>://000220237600005 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0731708503005612/1-s2.0-S0731708503005612-main.pdf?_tid=ca99cea28e37a9e2463320095358a3e3&acdnat=1333038818_ebd20d32b05b1dd92750c0ef2945b9fe | - |
| heal.journalName | J Pharm Biomed Anal | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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