The value of neuroendocrine markers in non-small cell lung cancer: a comparative immunohistopathologic study

Απλή σελίδα τεκμηρίου
dc.contributor.authorKiriakogiani-Psaropoulou, P.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorMartinopoulou, U.en
dc.contributor.authorLegaki, S.en
dc.contributor.authorTamvakis, N.en
dc.contributor.authorVrettou, E.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorSkarlos, D.en
dc.contributor.authorKosmidis, P.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T19:19:20Z
dc.date.available2015-11-24T19:19:20Z
dc.identifier.issn0169-5002-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21954
dc.rightsDefault Licence-
dc.subjectAntigens, CD/analysisen
dc.subjectAntigens, CD57en
dc.subjectAntigens, Differentiation, T-Lymphocyte/analysisen
dc.subjectBombesin/analysisen
dc.subjectCarcinoma, Non-Small-Cell Lung/*pathologyen
dc.subjectChromogranin Aen
dc.subjectChromogranins/analysisen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectLung Neoplasms/*pathologyen
dc.subjectNeurofilament Proteins/analysisen
dc.subjectPhosphopyruvate Hydratase/analysisen
dc.subjectTumor Markers, Biological/*analysisen
dc.titleThe value of neuroendocrine markers in non-small cell lung cancer: a comparative immunohistopathologic studyen
heal.abstractIn order to estimate the value of immunohistochemical identification of neuroendocrine (NE) differentiation markers in non-small cell lung carcinomas (NSCLCs), we investigated the expression of five neuroendocrine and neural differentiation-related antigens in 51 NSCLCs. Additionally, 20 epithelial lung tumors with NE differentiation [15 carcinoids and five small cell lung carcinomas (SCLCs)] and 61 epithelial tumors of various other origin (breast, prostate, colon and head-neck carcinomas) were studied. An indirect two-stage immunoperoxidase method was performed in formalin-fixed and paraffin-embedded tissue specimens, by using commercially available monoclonal antibodies. These antibodies are directed against neuron-specific enolase (NSE), chromogranin-A and Leu-7 which are general markers of NE differentiation, bombesin, which is a specific NE secretory product and neurofilament triplet protein (NFTP), an intermediate filament protein of neuronal differentiation. All five markers demonstrated a positive immunoreactivity in NSCLCs, equally distributed to all three histologic subtypes, ranging from 16 to 47% of the cases (NSE 47%, bombesin 21.5%, Leu-7 21.5%, chromogranin-A 18% and NFTP 16%). Most of the carcinoids and SCLCs expressed multiple or all NE markers. The other four epithelial tumors showed a positive immunoreactivity for bombesin, Leu-7 and NFTP, ranging from 11 to 40% of the cases. Chromogranin-A was not expressed in any of these tumors, whereas NSE was demonstrated only in 17% of breast carcinomas. The following remarks can be drawn from this study: (1) some NSCLCs showed immunophenotypic NE differentiation; (2) among all the markers used, NSE was the most sensitive (sensitivity, 100%) and chromogranin-A the most specific (specificity, 100%); and (3) NSE and chromogranin-A appear to be the most valuable and useful indicators of probable neuroendocrine differentiation in lung epithelial tumors.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7535640-
heal.identifier.secondaryhttp://ac.els-cdn.com/0169500294921644/1-s2.0-0169500294921644-main.pdf?_tid=acc56114eda3d09cfd9a18774d4a09b6&acdnat=1333611903_c4a720d229fc9572b02e4a65a2f995bb-
heal.journalNameLung Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ