Effects of non-steroid anti-inflammatory drugs in membrane bilayers
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kyrikou, I.
Hadjikakou, S. K.
Kovala-Demertzi, D.
Viras, K.
Mavromoustakos, T.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Chemistry and Physics of Lipids
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The thermal effects of non-steroidal anti-inflammatory drugs (NSAIDs) meloxicam, tenoxicam, piroxicam and lornoxicam have been studied in dipalmitoylphosphatidylcholine (DPPC) membrane bilayers using neutral and acidic environments (pH 2.5). The strength of the perturbing effect of the drugs is summarized to a lowering of the main phase transition temperature and a broadening of the phase transition temperature as well as broadening or abolishment of the pretransition of DPPC bilayers. The thermal profiles in the two environments were very similar. Among the NSAIDs studied meloxicam showed the least perturbing effect. The differential scanning calorimetry results (DSC) in combination with molecular modeling studies point out that NSAIDs are characterized by amphoteric interactions and are extended between the polar and hydrophobic segments of lipid bilayers. The effects of NSAIDs in membrane bilayers were also investigated using Raman spectroscopy. Meloxicam showed a gauche:trans profile similar to DPPC bilayers while the other NSAIDs increased significantly the gauche:trans ratio. In conclusion, both techniques show that in spite of the close structural similarity of the NSAIDs studied, meloxicam appears to have the lowest membrane perturbing effects probably attributed to its highest lipophilicity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
nsaids, lipid bilayers, molecular modeling, differential scanning calorimetry, raman spectroscopy, differential scanning calorimetry, metal-complexes, lipid-bilayers, raman-spectra, dipalmitoylphosphatidylcholine, osteoarthritis, spectroscopy, transition, disorder, steroids
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000225678200002
http://ac.els-cdn.com/S0009308404001252/1-s2.0-S0009308404001252-main.pdf?_tid=5480dd8482df1378c0af33c90421fccd&acdnat=1333030215_13af80fead01d1ca850c0abc41e597cd
http://ac.els-cdn.com/S0009308404001252/1-s2.0-S0009308404001252-main.pdf?_tid=5480dd8482df1378c0af33c90421fccd&acdnat=1333030215_13af80fead01d1ca850c0abc41e597cd
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας