Effects of non-steroid anti-inflammatory drugs in membrane bilayers
| dc.contributor.author | Kyrikou, I. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Viras, K. | en |
| dc.contributor.author | Mavromoustakos, T. | en |
| dc.date.accessioned | 2015-11-24T16:57:19Z | |
| dc.date.available | 2015-11-24T16:57:19Z | |
| dc.identifier.issn | 0009-3084 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10568 | |
| dc.rights | Default Licence | - |
| dc.subject | nsaids | en |
| dc.subject | lipid bilayers | en |
| dc.subject | molecular modeling | en |
| dc.subject | differential scanning calorimetry | en |
| dc.subject | raman spectroscopy | en |
| dc.subject | differential scanning calorimetry | en |
| dc.subject | metal-complexes | en |
| dc.subject | lipid-bilayers | en |
| dc.subject | raman-spectra | en |
| dc.subject | dipalmitoylphosphatidylcholine | en |
| dc.subject | osteoarthritis | en |
| dc.subject | spectroscopy | en |
| dc.subject | transition | en |
| dc.subject | disorder | en |
| dc.subject | steroids | en |
| dc.title | Effects of non-steroid anti-inflammatory drugs in membrane bilayers | en |
| heal.abstract | The thermal effects of non-steroidal anti-inflammatory drugs (NSAIDs) meloxicam, tenoxicam, piroxicam and lornoxicam have been studied in dipalmitoylphosphatidylcholine (DPPC) membrane bilayers using neutral and acidic environments (pH 2.5). The strength of the perturbing effect of the drugs is summarized to a lowering of the main phase transition temperature and a broadening of the phase transition temperature as well as broadening or abolishment of the pretransition of DPPC bilayers. The thermal profiles in the two environments were very similar. Among the NSAIDs studied meloxicam showed the least perturbing effect. The differential scanning calorimetry results (DSC) in combination with molecular modeling studies point out that NSAIDs are characterized by amphoteric interactions and are extended between the polar and hydrophobic segments of lipid bilayers. The effects of NSAIDs in membrane bilayers were also investigated using Raman spectroscopy. Meloxicam showed a gauche:trans profile similar to DPPC bilayers while the other NSAIDs increased significantly the gauche:trans ratio. In conclusion, both techniques show that in spite of the close structural similarity of the NSAIDs studied, meloxicam appears to have the lowest membrane perturbing effects probably attributed to its highest lipophilicity. (C) 2004 Elsevier Ireland Ltd. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1016/j.chemphyslip.2004.06.005 | - |
| heal.identifier.secondary | <Go to ISI>://000225678200002 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0009308404001252/1-s2.0-S0009308404001252-main.pdf?_tid=5480dd8482df1378c0af33c90421fccd&acdnat=1333030215_13af80fead01d1ca850c0abc41e597cd | - |
| heal.journalName | Chemistry and Physics of Lipids | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: